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Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems.
Pharmacol Biochem Behav 1998; 59(4):859-72PB

Abstract

Isolation rearing of rats produces a behavioral syndrome indicative of altered dopamine (DA) function in the nucleus accumbens (NAC). The present experiments extend these findings by investigating: (a) interactions between isolation rearing and repeated handling/testing on presynaptic DA function in the NAC using in vivo microdialysis: (b) the dose-response curve for the effects of d-amphetamine, and the responses elicited by high potassium, using in vivo microdialysis, and (c) postsynaptic function in isolates as indexed by DA receptor-linked cAMP production. Experiment 1 showed that both isolation rearing and repeated handling/testing had effects on monoamine function in the NAC. However, while both manipulations enhanced DA release evoked by d-amphetamine, only isolated rats had elevated basal DA levels. Opposite neurochemical changes were observed with respect to the serotonin metabolite 5-HIAA, isolates having lower, and repeatedly handled/tested animals having higher, extracellular levels. Experiment 2 provided evidence for enhanced d-amphetamine-evoked DA release in isolated animals, while potassium-evoked DA release was reduced. Experiment 3 provided evidence that the isolation rearing induced changes in presynaptic DA function were accompanied by postsynaptic changes. Specifically, the inhibitory influence of the D2 receptor on D1 receptor-stimulated cAMP production was attenuated in ventral striatal slices taken from isolates, suggesting a functional downregulation of D2 receptors.

Authors+Show Affiliations

Department of Experimental Psychology, University of Cambridge, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9586842

Citation

Hall, F S., et al. "Isolation Rearing in Rats: Pre- and Postsynaptic Changes in Striatal Dopaminergic Systems." Pharmacology, Biochemistry, and Behavior, vol. 59, no. 4, 1998, pp. 859-72.
Hall FS, Wilkinson LS, Humby T, et al. Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacol Biochem Behav. 1998;59(4):859-72.
Hall, F. S., Wilkinson, L. S., Humby, T., Inglis, W., Kendall, D. A., Marsden, C. A., & Robbins, T. W. (1998). Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry, and Behavior, 59(4), pp. 859-72.
Hall FS, et al. Isolation Rearing in Rats: Pre- and Postsynaptic Changes in Striatal Dopaminergic Systems. Pharmacol Biochem Behav. 1998;59(4):859-72. PubMed PMID: 9586842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. AU - Hall,F S, AU - Wilkinson,L S, AU - Humby,T, AU - Inglis,W, AU - Kendall,D A, AU - Marsden,C A, AU - Robbins,T W, PY - 1998/5/20/pubmed PY - 1998/5/20/medline PY - 1998/5/20/entrez SP - 859 EP - 72 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 59 IS - 4 N2 - Isolation rearing of rats produces a behavioral syndrome indicative of altered dopamine (DA) function in the nucleus accumbens (NAC). The present experiments extend these findings by investigating: (a) interactions between isolation rearing and repeated handling/testing on presynaptic DA function in the NAC using in vivo microdialysis: (b) the dose-response curve for the effects of d-amphetamine, and the responses elicited by high potassium, using in vivo microdialysis, and (c) postsynaptic function in isolates as indexed by DA receptor-linked cAMP production. Experiment 1 showed that both isolation rearing and repeated handling/testing had effects on monoamine function in the NAC. However, while both manipulations enhanced DA release evoked by d-amphetamine, only isolated rats had elevated basal DA levels. Opposite neurochemical changes were observed with respect to the serotonin metabolite 5-HIAA, isolates having lower, and repeatedly handled/tested animals having higher, extracellular levels. Experiment 2 provided evidence for enhanced d-amphetamine-evoked DA release in isolated animals, while potassium-evoked DA release was reduced. Experiment 3 provided evidence that the isolation rearing induced changes in presynaptic DA function were accompanied by postsynaptic changes. Specifically, the inhibitory influence of the D2 receptor on D1 receptor-stimulated cAMP production was attenuated in ventral striatal slices taken from isolates, suggesting a functional downregulation of D2 receptors. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/9586842/Isolation_rearing_in_rats:_pre__and_postsynaptic_changes_in_striatal_dopaminergic_systems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091305797005108 DB - PRIME DP - Unbound Medicine ER -