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RETRACTED ARTICLE

Anti-emetic efficacy of prophylactic granisetron, droperidol and metoclopramide in the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial.
Eur J Anaesthesiol. 1998 Mar; 15(2):166-71.EJ

Abstract

This study evaluates the prophylactic anti-emetic efficacy of granisetron, droperidol and metoclopramide, for the prevention of post-operative nausea and vomiting in female patients undergoing elective laparoscopic cholecystectomy. The patients were randomly assigned to one of four groups (n = 30 for each group): granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg and placebo (saline). These medications were given immediately before the induction of anaesthesia. During the first 24 h after anaesthesia, the incidence of post-operative nausea and vomiting was 13, 30, 33 and 37% after administration of granisetron, droperidol, metoclopramide and placebo, respectively (P < 0.05, overall Fisher's exact probability test). No clinically important adverse effects were observed in either group. Our results suggest that granisetron is a better anti-emetic than droperidol or metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy when compared with a placebo.

Authors+Show Affiliations

Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9587723

Citation

Fujii, Y, et al. "Anti-emetic Efficacy of Prophylactic Granisetron, Droperidol and Metoclopramide in the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy: a Randomized, Double-blind, Placebo-controlled Trial." European Journal of Anaesthesiology, vol. 15, no. 2, 1998, pp. 166-71.
Fujii Y, Saitoh Y, Tanaka H, et al. Anti-emetic efficacy of prophylactic granisetron, droperidol and metoclopramide in the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial. Eur J Anaesthesiol. 1998;15(2):166-71.
Fujii, Y., Saitoh, Y., Tanaka, H., & Toyooka, H. (1998). Anti-emetic efficacy of prophylactic granisetron, droperidol and metoclopramide in the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial. European Journal of Anaesthesiology, 15(2), 166-71.
Fujii Y, et al. Anti-emetic Efficacy of Prophylactic Granisetron, Droperidol and Metoclopramide in the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy: a Randomized, Double-blind, Placebo-controlled Trial. Eur J Anaesthesiol. 1998;15(2):166-71. PubMed PMID: 9587723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-emetic efficacy of prophylactic granisetron, droperidol and metoclopramide in the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial. AU - Fujii,Y, AU - Saitoh,Y, AU - Tanaka,H, AU - Toyooka,H, PY - 1998/5/20/pubmed PY - 1998/5/20/medline PY - 1998/5/20/entrez SP - 166 EP - 71 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 15 IS - 2 N2 - This study evaluates the prophylactic anti-emetic efficacy of granisetron, droperidol and metoclopramide, for the prevention of post-operative nausea and vomiting in female patients undergoing elective laparoscopic cholecystectomy. The patients were randomly assigned to one of four groups (n = 30 for each group): granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg and placebo (saline). These medications were given immediately before the induction of anaesthesia. During the first 24 h after anaesthesia, the incidence of post-operative nausea and vomiting was 13, 30, 33 and 37% after administration of granisetron, droperidol, metoclopramide and placebo, respectively (P < 0.05, overall Fisher's exact probability test). No clinically important adverse effects were observed in either group. Our results suggest that granisetron is a better anti-emetic than droperidol or metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy when compared with a placebo. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/9587723/Anti_emetic_efficacy_of_prophylactic_granisetron_droperidol_and_metoclopramide_in_the_prevention_of_nausea_and_vomiting_after_laparoscopic_cholecystectomy:_a_randomized_double_blind_placebo_controlled_trial_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9587723.ui DB - PRIME DP - Unbound Medicine ER -