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Hip fracture risk in older white men is associated with change in body weight from age 50 years to old age.

Abstract

BACKGROUND

Change in body weight is a potentially modifiable risk factor for hip fracture in older women but, to our knowledge, its relationship to risk in older men has not been reported previously.

OBJECTIVE

To investigate the effects of weight loss and weight gain from age 50 years to old age on the risk of hip fracture among elderly men.

METHODS

The association between weight change and risk of hip fracture was studied in a cohort of 2413 community-dwelling white men aged 67 years or older from 3 sites of the Established Populations for Epidemiologic Study of the Elderly.

RESULTS

The older men in this study, observed for a total of 13620 person-years during the 8 years of follow-up, experienced 72 hip fractures, yielding an overall incidence rate of 5.3 per 1000 person-years. Extreme weight loss (> or =10%) beginning at age 50 years was associated in a proportional hazards model with increased risk of hip fracture (relative risk, 1.8; 95% confidence interval, 1.04-3.3). Weight loss of 10% or more was associated with several indicators of poor health, including physical disability, low mental status score, and low physical activity (P<.05). Weight gain of 10% or more beginning at age 50 years provided borderline protection against the risk of hip fracture (relative risk, 0.4; 95% confidence interval, 0.1-1.00).

CONCLUSIONS

Despite differences between older men and women in the incidence of and risk factors for hip fracture, weight history is also an important determinant of the risk of hip fracture among older men. Weight loss of 10% or more beginning at age 50 years increases the risk of hip fracture in older white men; weight gain of 10% or more decreases the risk of hip fracture. The relationship between extreme weight loss and poor health suggests that weight loss is a marker of frailty that may increase the risk of hip fracture in older men. Physicians should include weight history in their assessment of the risk of hip fracture among older men.

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  • Authors+Show Affiliations

    ,

    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD, USA.

    , , , ,

    Source

    Archives of internal medicine 158:9 1998 May 11 pg 990-6

    MeSH

    Aged
    Aged, 80 and over
    Hip Fractures
    Humans
    Incidence
    Male
    Middle Aged
    Risk
    Risk Factors
    United States
    Weight Gain
    Weight Loss

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    9588432

    Citation

    Langlois, J A., et al. "Hip Fracture Risk in Older White Men Is Associated With Change in Body Weight From Age 50 Years to Old Age." Archives of Internal Medicine, vol. 158, no. 9, 1998, pp. 990-6.
    Langlois JA, Visser M, Davidovic LS, et al. Hip fracture risk in older white men is associated with change in body weight from age 50 years to old age. Arch Intern Med. 1998;158(9):990-6.
    Langlois, J. A., Visser, M., Davidovic, L. S., Maggi, S., Li, G., & Harris, T. B. (1998). Hip fracture risk in older white men is associated with change in body weight from age 50 years to old age. Archives of Internal Medicine, 158(9), pp. 990-6.
    Langlois JA, et al. Hip Fracture Risk in Older White Men Is Associated With Change in Body Weight From Age 50 Years to Old Age. Arch Intern Med. 1998 May 11;158(9):990-6. PubMed PMID: 9588432.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hip fracture risk in older white men is associated with change in body weight from age 50 years to old age. AU - Langlois,J A, AU - Visser,M, AU - Davidovic,L S, AU - Maggi,S, AU - Li,G, AU - Harris,T B, PY - 1998/5/20/pubmed PY - 1998/5/20/medline PY - 1998/5/20/entrez SP - 990 EP - 6 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 158 IS - 9 N2 - BACKGROUND: Change in body weight is a potentially modifiable risk factor for hip fracture in older women but, to our knowledge, its relationship to risk in older men has not been reported previously. OBJECTIVE: To investigate the effects of weight loss and weight gain from age 50 years to old age on the risk of hip fracture among elderly men. METHODS: The association between weight change and risk of hip fracture was studied in a cohort of 2413 community-dwelling white men aged 67 years or older from 3 sites of the Established Populations for Epidemiologic Study of the Elderly. RESULTS: The older men in this study, observed for a total of 13620 person-years during the 8 years of follow-up, experienced 72 hip fractures, yielding an overall incidence rate of 5.3 per 1000 person-years. Extreme weight loss (> or =10%) beginning at age 50 years was associated in a proportional hazards model with increased risk of hip fracture (relative risk, 1.8; 95% confidence interval, 1.04-3.3). Weight loss of 10% or more was associated with several indicators of poor health, including physical disability, low mental status score, and low physical activity (P<.05). Weight gain of 10% or more beginning at age 50 years provided borderline protection against the risk of hip fracture (relative risk, 0.4; 95% confidence interval, 0.1-1.00). CONCLUSIONS: Despite differences between older men and women in the incidence of and risk factors for hip fracture, weight history is also an important determinant of the risk of hip fracture among older men. Weight loss of 10% or more beginning at age 50 years increases the risk of hip fracture in older white men; weight gain of 10% or more decreases the risk of hip fracture. The relationship between extreme weight loss and poor health suggests that weight loss is a marker of frailty that may increase the risk of hip fracture in older men. Physicians should include weight history in their assessment of the risk of hip fracture among older men. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/9588432/Hip_fracture_risk_in_older_white_men_is_associated_with_change_in_body_weight_from_age_50_years_to_old_age_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/158/pg/990 DB - PRIME DP - Unbound Medicine ER -