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Manometry and 24-hour ambulatory pH monitoring at two levels of the esophagus in patients with and without esophagitis.
Rev Esp Enferm Dig. 1998 Mar; 90(3):145-54.RE

Abstract

OBJECTIVE

To define the relationship between esophageal dysmotility and severity of gastroesophageal reflux (GER) at the distal and proximal levels.

METHODS

Two-level, 24-hour ambulatory pH monitoring and manometry of the esophagus were performed in 40 patients with abnormal distal acid exposure and in 20 healthy controls. Twenty patients with normal endoscopy or endoscopic evidence of grade I esophagitis were assigned to group 1 and 20 with grade II-III esophagitis were assigned to group 2. We used a dual-site pH probe with antimony electrodes spaced 15 cm apart.

RESULTS

Patients had greater acid exposure than controls at both levels. The percentage of distal reflux episodes reaching proximal esophagus was significantly greater in group 1 than in the control group. The most marked reductions in the percentage of time of the pH remaining under 4 were detected in the patients with the most severe distal acid reflux and esophagitis (group 2). The mean lower esophageal sphincter pressure was significantly lower in group 2 than in group 1. The percentage of tertiary waves or nonperistaltic contractions was significantly higher in group 2 than in group 1 and the control group. Patients with milder distal reflux had significantly lower distal and middle esophageal wave amplitudes than controls. There were no significant differences between controls and patients with severe esophagitis in terms of the esophageal peristaltic wave amplitude in the middle third of the esophagus.

CONCLUSIONS

No correlation was observed between episodes of distal reflux and proximal reflux in GER patients. Esophageal motor activity appears to be an important determinant of the severity and extension of GER in the proximal esophagus.

Authors+Show Affiliations

Service of Digestive Diseases, San Carlos University Hospital, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

9595935

Citation

Sevilla Mantilla, M C., et al. "Manometry and 24-hour Ambulatory pH Monitoring at Two Levels of the Esophagus in Patients With and Without Esophagitis." Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, vol. 90, no. 3, 1998, pp. 145-54.
Sevilla Mantilla MC, Ruiz de León A, Pérez de la Serna J, et al. Manometry and 24-hour ambulatory pH monitoring at two levels of the esophagus in patients with and without esophagitis. Rev Esp Enferm Dig. 1998;90(3):145-54.
Sevilla Mantilla, M. C., Ruiz de León, A., Pérez de la Serna, J., Taxonera, C., García Paredes, J., & Díaz Rubio, M. (1998). Manometry and 24-hour ambulatory pH monitoring at two levels of the esophagus in patients with and without esophagitis. Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, 90(3), 145-54.
Sevilla Mantilla MC, et al. Manometry and 24-hour Ambulatory pH Monitoring at Two Levels of the Esophagus in Patients With and Without Esophagitis. Rev Esp Enferm Dig. 1998;90(3):145-54. PubMed PMID: 9595935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Manometry and 24-hour ambulatory pH monitoring at two levels of the esophagus in patients with and without esophagitis. AU - Sevilla Mantilla,M C, AU - Ruiz de León,A, AU - Pérez de la Serna,J, AU - Taxonera,C, AU - García Paredes,J, AU - Díaz Rubio,M, PY - 1998/5/22/pubmed PY - 1998/5/22/medline PY - 1998/5/22/entrez SP - 145 EP - 54 JF - Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva JO - Rev Esp Enferm Dig VL - 90 IS - 3 N2 - OBJECTIVE: To define the relationship between esophageal dysmotility and severity of gastroesophageal reflux (GER) at the distal and proximal levels. METHODS: Two-level, 24-hour ambulatory pH monitoring and manometry of the esophagus were performed in 40 patients with abnormal distal acid exposure and in 20 healthy controls. Twenty patients with normal endoscopy or endoscopic evidence of grade I esophagitis were assigned to group 1 and 20 with grade II-III esophagitis were assigned to group 2. We used a dual-site pH probe with antimony electrodes spaced 15 cm apart. RESULTS: Patients had greater acid exposure than controls at both levels. The percentage of distal reflux episodes reaching proximal esophagus was significantly greater in group 1 than in the control group. The most marked reductions in the percentage of time of the pH remaining under 4 were detected in the patients with the most severe distal acid reflux and esophagitis (group 2). The mean lower esophageal sphincter pressure was significantly lower in group 2 than in group 1. The percentage of tertiary waves or nonperistaltic contractions was significantly higher in group 2 than in group 1 and the control group. Patients with milder distal reflux had significantly lower distal and middle esophageal wave amplitudes than controls. There were no significant differences between controls and patients with severe esophagitis in terms of the esophageal peristaltic wave amplitude in the middle third of the esophagus. CONCLUSIONS: No correlation was observed between episodes of distal reflux and proximal reflux in GER patients. Esophageal motor activity appears to be an important determinant of the severity and extension of GER in the proximal esophagus. SN - 1130-0108 UR - https://www.unboundmedicine.com/medline/citation/9595935/Manometry_and_24_hour_ambulatory_pH_monitoring_at_two_levels_of_the_esophagus_in_patients_with_and_without_esophagitis_ DB - PRIME DP - Unbound Medicine ER -