Tags

Type your tag names separated by a space and hit enter

[Acute fatty liver in pregnancy: a clinicopathologic study].
Zhonghua Fu Chan Ke Za Zhi. 1997 Feb; 32(2):74-7.ZF

Abstract

OBJECTIVE

To investigate the early recognition and management of milder cases of acute fatty liver in pregnancy (AFLP).

METHODS

Twelve cases of AFLP treated in our hospital during the past two and half years were retrospectively studied with emphasis on symptoms, laboratory findings, liver biopsy and maternal complications. The 12 cases were classified into 2 groups. Group 1, 6 cases of advanced AFLP diagnosed clinically, were treated in the first year of the study. Group 2, 6 cases of milder AFLP diagnosed by postpartum liver biopsy, were treated during the last one and half years of the study.

RESULTS

The mean gestational age at onset was 34 +/- 3 weeks. In the early stage, all cases had malaise, nausea, loss of appetite and epigastric distress followed by jaundice in the third trimester of pregnancy. Laboratory findings included raised transaminases (< or = 300 IU/L) and total serum bilirubin (32.5-510.8 micro mol/L) levels, hypoalbuminemia (18-30 g/L), hypofibrogenemia (< 2.4 g/L), prolonged prothrombin time and prolonged partial thromboplastin time. Maternal complications were frequent including hepatic encephalopathy (9), ascites (9), hypoglycemia (7), renal failure (3), hematemesis (4), preeclampsia (6), and postpartum hemorrhage (5). Cesarean sections were performed in 7 cases. In group 2, both mother and fetuses had 100% survival. However, the mortality of the mothers and fetuses in group 1 were both 50%.

CONCLUSIONS

With increasing awareness, especially in the early recognition of AFLP cases and prompt progressive management, including early termination of pregnancy and large dose infusion of fresh frozen plasma, the prognosis of AFLP is obviously improved. Percutaneous liver biopsy should be done when the coagulation tests became normal and the amounts of ascites decreased after delivery.

Authors+Show Affiliations

Yang W
First Affiliated Hospital, Suzhou Medical College.
Shen Z
No affiliation info available
Cheng Y
No affiliation info available

MeSH

Acute DiseaseAdultDiagnosis, DifferentialFatty LiverFemaleHumansLiverPregnancyPregnancy ComplicationsRetrospective Studies

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

9596873

Citation

Yang, W, et al. "[Acute Fatty Liver in Pregnancy: a Clinicopathologic Study]." Zhonghua Fu Chan Ke Za Zhi, vol. 32, no. 2, 1997, pp. 74-7.
Yang W, Shen Z, Cheng Y. [Acute fatty liver in pregnancy: a clinicopathologic study]. Zhonghua Fu Chan Ke Za Zhi. 1997;32(2):74-7.
Yang, W., Shen, Z., & Cheng, Y. (1997). [Acute fatty liver in pregnancy: a clinicopathologic study]. Zhonghua Fu Chan Ke Za Zhi, 32(2), 74-7.
Yang W, Shen Z, Cheng Y. [Acute Fatty Liver in Pregnancy: a Clinicopathologic Study]. Zhonghua Fu Chan Ke Za Zhi. 1997;32(2):74-7. PubMed PMID: 9596873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute fatty liver in pregnancy: a clinicopathologic study]. AU - Yang,W, AU - Shen,Z, AU - Cheng,Y, PY - 1997/2/1/pubmed PY - 1998/5/23/medline PY - 1997/2/1/entrez SP - 74 EP - 7 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 32 IS - 2 N2 - OBJECTIVE: To investigate the early recognition and management of milder cases of acute fatty liver in pregnancy (AFLP). METHODS: Twelve cases of AFLP treated in our hospital during the past two and half years were retrospectively studied with emphasis on symptoms, laboratory findings, liver biopsy and maternal complications. The 12 cases were classified into 2 groups. Group 1, 6 cases of advanced AFLP diagnosed clinically, were treated in the first year of the study. Group 2, 6 cases of milder AFLP diagnosed by postpartum liver biopsy, were treated during the last one and half years of the study. RESULTS: The mean gestational age at onset was 34 +/- 3 weeks. In the early stage, all cases had malaise, nausea, loss of appetite and epigastric distress followed by jaundice in the third trimester of pregnancy. Laboratory findings included raised transaminases (< or = 300 IU/L) and total serum bilirubin (32.5-510.8 micro mol/L) levels, hypoalbuminemia (18-30 g/L), hypofibrogenemia (< 2.4 g/L), prolonged prothrombin time and prolonged partial thromboplastin time. Maternal complications were frequent including hepatic encephalopathy (9), ascites (9), hypoglycemia (7), renal failure (3), hematemesis (4), preeclampsia (6), and postpartum hemorrhage (5). Cesarean sections were performed in 7 cases. In group 2, both mother and fetuses had 100% survival. However, the mortality of the mothers and fetuses in group 1 were both 50%. CONCLUSIONS: With increasing awareness, especially in the early recognition of AFLP cases and prompt progressive management, including early termination of pregnancy and large dose infusion of fresh frozen plasma, the prognosis of AFLP is obviously improved. Percutaneous liver biopsy should be done when the coagulation tests became normal and the amounts of ascites decreased after delivery. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/9596873/[Acute_fatty_liver_in_pregnancy:_a_clinicopathologic_study]_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -