Tags

Type your tag names separated by a space and hit enter

[The effects of hyperinsulinmia and insulin-like growth factor-1 on hyperandrogenism in polycystic ovarian syndrome].
Zhonghua Yi Xue Za Zhi. 1997 Apr; 77(4):266-9.ZY

Abstract

OBJECTIVE

To investigate the effects of insulin (INS) and insulin-like growth factor-1 (IGF-1) on ovarian androgen production in women with polycystic ovarian syndrome (PCOS).

METHOD

48 patients with PCOS were divided into two groups based on body mass index (BMI) (24 were obese BMI > 25 and 24 nonobese) (BMI < 25). 10 women with normal weight and menstruation were recruited as controls. The serum LH, FSH and testosterone (T) levels were determined. 40 cases were measured INS, IGF-1, androstenodine (A) and sex hormone binding globulin (SHBG) after a 3-hour oral glucose tolerance test (OGTT). Ovarian stroma obtained from 10 patients with PCOS and 5 healthy women were cultured in the medium with high INS concentration (30 ng/ml and 60 ng/ml). The IGF-1 and A levels were determined.

RESULTS

Two groups of patients with PCOS demonstrated significant hyperinsulinmia (HI) and hyperandrogenism. Significantly higher IGF-1 level was observed in nonobese patients (P < 0.01). Insulin markedly stimulated release of IGF-1 (4 times, P < 0.01) and A (6 times, P < 0.05) in incubation of ovarian stroma obtained from PCOS patients. A positive correlation between IGF-1 and A was present in the culture medium (r = 0.679, P < 0.05). The serum levels of SHBG were significantly lower in PCOS patients.

CONCLUSION

The findings suggest that the women with PCOS have HI, since INS may play an important role in hyperandrogenism by upregulating IGF-1 system in ovary.

Authors+Show Affiliations

Department of Gynecology & Obstetrics, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

9596926

Citation

Liang, X, et al. "[The Effects of Hyperinsulinmia and Insulin-like Growth Factor-1 On Hyperandrogenism in Polycystic Ovarian Syndrome]." Zhonghua Yi Xue Za Zhi, vol. 77, no. 4, 1997, pp. 266-9.
Liang X, Zhuang G, Fan Q. [The effects of hyperinsulinmia and insulin-like growth factor-1 on hyperandrogenism in polycystic ovarian syndrome]. Zhonghua Yi Xue Za Zhi. 1997;77(4):266-9.
Liang, X., Zhuang, G., & Fan, Q. (1997). [The effects of hyperinsulinmia and insulin-like growth factor-1 on hyperandrogenism in polycystic ovarian syndrome]. Zhonghua Yi Xue Za Zhi, 77(4), 266-9.
Liang X, Zhuang G, Fan Q. [The Effects of Hyperinsulinmia and Insulin-like Growth Factor-1 On Hyperandrogenism in Polycystic Ovarian Syndrome]. Zhonghua Yi Xue Za Zhi. 1997;77(4):266-9. PubMed PMID: 9596926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effects of hyperinsulinmia and insulin-like growth factor-1 on hyperandrogenism in polycystic ovarian syndrome]. AU - Liang,X, AU - Zhuang,G, AU - Fan,Q, PY - 1997/4/1/pubmed PY - 1998/5/23/medline PY - 1997/4/1/entrez SP - 266 EP - 9 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 77 IS - 4 N2 - OBJECTIVE: To investigate the effects of insulin (INS) and insulin-like growth factor-1 (IGF-1) on ovarian androgen production in women with polycystic ovarian syndrome (PCOS). METHOD: 48 patients with PCOS were divided into two groups based on body mass index (BMI) (24 were obese BMI > 25 and 24 nonobese) (BMI < 25). 10 women with normal weight and menstruation were recruited as controls. The serum LH, FSH and testosterone (T) levels were determined. 40 cases were measured INS, IGF-1, androstenodine (A) and sex hormone binding globulin (SHBG) after a 3-hour oral glucose tolerance test (OGTT). Ovarian stroma obtained from 10 patients with PCOS and 5 healthy women were cultured in the medium with high INS concentration (30 ng/ml and 60 ng/ml). The IGF-1 and A levels were determined. RESULTS: Two groups of patients with PCOS demonstrated significant hyperinsulinmia (HI) and hyperandrogenism. Significantly higher IGF-1 level was observed in nonobese patients (P < 0.01). Insulin markedly stimulated release of IGF-1 (4 times, P < 0.01) and A (6 times, P < 0.05) in incubation of ovarian stroma obtained from PCOS patients. A positive correlation between IGF-1 and A was present in the culture medium (r = 0.679, P < 0.05). The serum levels of SHBG were significantly lower in PCOS patients. CONCLUSION: The findings suggest that the women with PCOS have HI, since INS may play an important role in hyperandrogenism by upregulating IGF-1 system in ovary. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/9596926/[The_effects_of_hyperinsulinmia_and_insulin_like_growth_factor_1_on_hyperandrogenism_in_polycystic_ovarian_syndrome]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=1997&amp;vol=77&amp;issue=4&amp;fpage=266 DB - PRIME DP - Unbound Medicine ER -