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Re-evaluation of i.m. ephedrine as prophylaxis against hypotension associated with spinal anaesthesia for Caesarean section.
Can J Anaesth. 1998 Apr; 45(4):367-9.CJ

Abstract

PURPOSE

To assess the safety and efficacy of 37.5 mg ephedrine i.m. in preventing hypotension associated with spinal anaesthesia for Caesarean section.

METHODS

In a double-blind randomised controlled study, 40 patients (20 in each group) were given either 37.5 mg ephedrine or placebo i.m. The following parameters were recorded: (i) blood pressure; (ii) heart rate; (iii) ephedrine i.v. supplementation; (iv) umbilical venous blood gases and neonatal Apgar scores.

RESULTS

The incidence of hypertension in the study group was 30% compared with 20% for the control group (P:NS). There was no difference in mean highest blood pressure or mean highest heart rate between the groups. The incidence of hypotension was lower but not significantly lower in the study group (50%) than in the control group (80%) (P:NS). However, the incidence of delayed hypotension was only 10% in the study group patients compared with 50% in the control group patients (P < 0.05).

CONCLUSION

Giving 37.5 mg ephedrine i.m. prior to spinal anaesthesia was not associated with reactive hypertension or tachycardia. Intramuscular ephedrine provided more sustained cardiovascular support than intravenous ephedrine.

Authors+Show Affiliations

Department of Anaesthesiology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9597213

Citation

Webb, A A., and E A. Shipton. "Re-evaluation of I.m. Ephedrine as Prophylaxis Against Hypotension Associated With Spinal Anaesthesia for Caesarean Section." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 45, no. 4, 1998, pp. 367-9.
Webb AA, Shipton EA. Re-evaluation of i.m. ephedrine as prophylaxis against hypotension associated with spinal anaesthesia for Caesarean section. Can J Anaesth. 1998;45(4):367-9.
Webb, A. A., & Shipton, E. A. (1998). Re-evaluation of i.m. ephedrine as prophylaxis against hypotension associated with spinal anaesthesia for Caesarean section. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 45(4), 367-9.
Webb AA, Shipton EA. Re-evaluation of I.m. Ephedrine as Prophylaxis Against Hypotension Associated With Spinal Anaesthesia for Caesarean Section. Can J Anaesth. 1998;45(4):367-9. PubMed PMID: 9597213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Re-evaluation of i.m. ephedrine as prophylaxis against hypotension associated with spinal anaesthesia for Caesarean section. AU - Webb,A A, AU - Shipton,E A, PY - 1998/5/23/pubmed PY - 1998/5/23/medline PY - 1998/5/23/entrez SP - 367 EP - 9 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 45 IS - 4 N2 - PURPOSE: To assess the safety and efficacy of 37.5 mg ephedrine i.m. in preventing hypotension associated with spinal anaesthesia for Caesarean section. METHODS: In a double-blind randomised controlled study, 40 patients (20 in each group) were given either 37.5 mg ephedrine or placebo i.m. The following parameters were recorded: (i) blood pressure; (ii) heart rate; (iii) ephedrine i.v. supplementation; (iv) umbilical venous blood gases and neonatal Apgar scores. RESULTS: The incidence of hypertension in the study group was 30% compared with 20% for the control group (P:NS). There was no difference in mean highest blood pressure or mean highest heart rate between the groups. The incidence of hypotension was lower but not significantly lower in the study group (50%) than in the control group (80%) (P:NS). However, the incidence of delayed hypotension was only 10% in the study group patients compared with 50% in the control group patients (P < 0.05). CONCLUSION: Giving 37.5 mg ephedrine i.m. prior to spinal anaesthesia was not associated with reactive hypertension or tachycardia. Intramuscular ephedrine provided more sustained cardiovascular support than intravenous ephedrine. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/9597213/Re_evaluation_of_i_m__ephedrine_as_prophylaxis_against_hypotension_associated_with_spinal_anaesthesia_for_Caesarean_section_ L2 - https://dx.doi.org/10.1007/BF03012030 DB - PRIME DP - Unbound Medicine ER -