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Bacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media.
J Antimicrob Chemother. 1998 Apr; 41(4):489-92.JA

Abstract

The effect on the nasopharyngeal bacterial flora of therapy for 10 days with co-amoxiclav or cefprozil was studied in 50 children with acute otitis media. Before therapy, potential pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) were isolated in 14 (56%) of those treated with co-amoxiclav and 15 (60%) of those treated with cefprozil. Following therapy, the reduction in the number of these pathogens was the same in the two groups. However, differences between the groups were noted in the recovery of organisms with interfering capability, namely alpha-haemolytic streptococci, Peptostreptococcus anaerobius and Prevotella melaninogenica. Fifty interfering organisms were recovered from each group before therapy. After therapy with co-amoxiclav or cefprozil their number declined to 11 and 42, respectively (P< 0.001).

Authors+Show Affiliations

Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9598781

Citation

Brook, I, and A E. Gober. "Bacterial Interference in the Nasopharynx Following Antimicrobial Therapy of Acute Otitis Media." The Journal of Antimicrobial Chemotherapy, vol. 41, no. 4, 1998, pp. 489-92.
Brook I, Gober AE. Bacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media. J Antimicrob Chemother. 1998;41(4):489-92.
Brook, I., & Gober, A. E. (1998). Bacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media. The Journal of Antimicrobial Chemotherapy, 41(4), 489-92.
Brook I, Gober AE. Bacterial Interference in the Nasopharynx Following Antimicrobial Therapy of Acute Otitis Media. J Antimicrob Chemother. 1998;41(4):489-92. PubMed PMID: 9598781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media. AU - Brook,I, AU - Gober,A E, PY - 1998/5/23/pubmed PY - 1998/5/23/medline PY - 1998/5/23/entrez SP - 489 EP - 92 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 41 IS - 4 N2 - The effect on the nasopharyngeal bacterial flora of therapy for 10 days with co-amoxiclav or cefprozil was studied in 50 children with acute otitis media. Before therapy, potential pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) were isolated in 14 (56%) of those treated with co-amoxiclav and 15 (60%) of those treated with cefprozil. Following therapy, the reduction in the number of these pathogens was the same in the two groups. However, differences between the groups were noted in the recovery of organisms with interfering capability, namely alpha-haemolytic streptococci, Peptostreptococcus anaerobius and Prevotella melaninogenica. Fifty interfering organisms were recovered from each group before therapy. After therapy with co-amoxiclav or cefprozil their number declined to 11 and 42, respectively (P< 0.001). SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/9598781/Bacterial_interference_in_the_nasopharynx_following_antimicrobial_therapy_of_acute_otitis_media_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/41.4.489 DB - PRIME DP - Unbound Medicine ER -