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Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13.
Genes Chromosomes Cancer. 1998 Jun; 22(2):130-7.GC

Abstract

Multiple endocrine neoplasia type 1 syndrome (MEN1, MIM 131100), an autosomal dominant disease, is characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. These tumors also occur sporadically. Both the familial (MEN1) and the sporadic tumors reveal loss of heterozygosity (LOH) for chromosome band 11q13 sequences. Based on prior linkage and LOH analyses, the MEN1 gene was localized between PYGM and D11S460. Recently, the MEN1 gene (menin) has been cloned from sequences 30-kb distal to PYGM. We performed deletion mapping on 25 endocrine tumors (5 MEN1 and 20 sporadic) by using 21 polymorphic markers on chromosome band 11q13. Of these, two (137C7A, 137C7B) were derived from PYGM-containing BAC (bacterial artificial chromosome-137C7) sequences, one from INT2-containing cosmid sequences and the marker D11S4748, a (CA)20 repeat marker that was developed by us. The LOH analysis shows that the markers close to the MEN1 (menin) gene were not deleted in three of the tumors. These tumors, however, showed LOH for distal markers. Thus, the data suggest the existence of a second tumor suppressor gene on chromosome band 11q13.

Authors+Show Affiliations

Department of Surgery, VAMC West Los Angeles, UCLA School of Medicine, California 90073, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9598800

Citation

Chakrabarti, R, et al. "Deletion Mapping of Endocrine Tumors Localizes a Second Tumor Suppressor Gene On Chromosome Band 11q13." Genes, Chromosomes & Cancer, vol. 22, no. 2, 1998, pp. 130-7.
Chakrabarti R, Srivatsan ES, Wood TF, et al. Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. Genes Chromosomes Cancer. 1998;22(2):130-7.
Chakrabarti, R., Srivatsan, E. S., Wood, T. F., Eubanks, P. J., Ebrahimi, S. A., Gatti, R. A., Passaro, E., & Sawicki, M. P. (1998). Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. Genes, Chromosomes & Cancer, 22(2), 130-7.
Chakrabarti R, et al. Deletion Mapping of Endocrine Tumors Localizes a Second Tumor Suppressor Gene On Chromosome Band 11q13. Genes Chromosomes Cancer. 1998;22(2):130-7. PubMed PMID: 9598800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. AU - Chakrabarti,R, AU - Srivatsan,E S, AU - Wood,T F, AU - Eubanks,P J, AU - Ebrahimi,S A, AU - Gatti,R A, AU - Passaro,E,Jr AU - Sawicki,M P, PY - 1998/5/23/pubmed PY - 2000/6/20/medline PY - 1998/5/23/entrez SP - 130 EP - 7 JF - Genes, chromosomes & cancer JO - Genes Chromosomes Cancer VL - 22 IS - 2 N2 - Multiple endocrine neoplasia type 1 syndrome (MEN1, MIM 131100), an autosomal dominant disease, is characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. These tumors also occur sporadically. Both the familial (MEN1) and the sporadic tumors reveal loss of heterozygosity (LOH) for chromosome band 11q13 sequences. Based on prior linkage and LOH analyses, the MEN1 gene was localized between PYGM and D11S460. Recently, the MEN1 gene (menin) has been cloned from sequences 30-kb distal to PYGM. We performed deletion mapping on 25 endocrine tumors (5 MEN1 and 20 sporadic) by using 21 polymorphic markers on chromosome band 11q13. Of these, two (137C7A, 137C7B) were derived from PYGM-containing BAC (bacterial artificial chromosome-137C7) sequences, one from INT2-containing cosmid sequences and the marker D11S4748, a (CA)20 repeat marker that was developed by us. The LOH analysis shows that the markers close to the MEN1 (menin) gene were not deleted in three of the tumors. These tumors, however, showed LOH for distal markers. Thus, the data suggest the existence of a second tumor suppressor gene on chromosome band 11q13. SN - 1045-2257 UR - https://www.unboundmedicine.com/medline/citation/9598800/Deletion_mapping_of_endocrine_tumors_localizes_a_second_tumor_suppressor_gene_on_chromosome_band_11q13_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1045-2257&date=1998&volume=22&issue=2&spage=130 DB - PRIME DP - Unbound Medicine ER -