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Primary Sjögren's syndrome: role of the HLA-DRB1*0301-*1501 heterozygotes.
J Rheumatol. 1998 May; 25(5):900-5.JR

Abstract

OBJECTIVE

To examine the respective role of the DRB1*, DQB1*, and DPB1* HLA alleles in primary Sjögren's syndrome (SS) and in the clinical and autoantibody profile of primary SS.

METHODS

HLA-DRB1*, DQB1*, and DPB1* alleles were analyzed in 42 patients with primary SS and 200 controls by reverse dot blot hybridization for DRB1* and DPB1* and by polymerase chain reaction-restriction fragment length polymorphism for DQB1*.

RESULTS

We found a significant increase of the HLA-DRB1*15-*03 heterozygote genotype frequency (19% primary SS vs 3.5% controls; p<0.0006, OR=6.49) and especially for the HLA-DRBI*1501-*0301 genotype (16.7% primary SS vs 3% controls; p<0.002, OR=6.47). The DQB1*0201-*0602 genotype was also significantly increased in primary SS (17.1% primary SS vs 4% controls; p<0.006, OR=4.86). However, the higher risk to primary SS development was associated with the DRB1*1501-*0301 genotype (OR=6.47 vs 4.86). There were no differences between patients and controls in DPB1* allele frequencies. The HLA-DRB1*15-*03 heterozygote genotype was also associated with systemic features such as hematologic manifestations and Raynaud's phenomenon (RP) and with autoantibody production such as antinuclear, anti-Ro(SSA) or La(SSB) autoantibodies and rheumatoid factor.

CONCLUSION

Our data suggest a role of the HLA-DRB1*1501-*0301 heterozygote genotype in susceptibility to primary SS. Moreover, the HLA-DRB1*1501-*0301 genotype was also found to be associated with a particular form of the disease characterized by RP, hematologic manifestations, and autoantibody production.

Authors+Show Affiliations

Department of Rheumatology, University Hospital Rennes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9598888

Citation

Guggenbuhl, P, et al. "Primary Sjögren's Syndrome: Role of the HLA-DRB1*0301-*1501 Heterozygotes." The Journal of Rheumatology, vol. 25, no. 5, 1998, pp. 900-5.
Guggenbuhl P, Jean S, Jego P, et al. Primary Sjögren's syndrome: role of the HLA-DRB1*0301-*1501 heterozygotes. J Rheumatol. 1998;25(5):900-5.
Guggenbuhl, P., Jean, S., Jego, P., Grosbois, B., Chalès, G., Semana, G., Lancien, G., Veillard, E., Pawlotsky, Y., & Perdriger, A. (1998). Primary Sjögren's syndrome: role of the HLA-DRB1*0301-*1501 heterozygotes. The Journal of Rheumatology, 25(5), 900-5.
Guggenbuhl P, et al. Primary Sjögren's Syndrome: Role of the HLA-DRB1*0301-*1501 Heterozygotes. J Rheumatol. 1998;25(5):900-5. PubMed PMID: 9598888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary Sjögren's syndrome: role of the HLA-DRB1*0301-*1501 heterozygotes. AU - Guggenbuhl,P, AU - Jean,S, AU - Jego,P, AU - Grosbois,B, AU - Chalès,G, AU - Semana,G, AU - Lancien,G, AU - Veillard,E, AU - Pawlotsky,Y, AU - Perdriger,A, PY - 1998/5/23/pubmed PY - 1998/5/23/medline PY - 1998/5/23/entrez SP - 900 EP - 5 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 25 IS - 5 N2 - OBJECTIVE: To examine the respective role of the DRB1*, DQB1*, and DPB1* HLA alleles in primary Sjögren's syndrome (SS) and in the clinical and autoantibody profile of primary SS. METHODS: HLA-DRB1*, DQB1*, and DPB1* alleles were analyzed in 42 patients with primary SS and 200 controls by reverse dot blot hybridization for DRB1* and DPB1* and by polymerase chain reaction-restriction fragment length polymorphism for DQB1*. RESULTS: We found a significant increase of the HLA-DRB1*15-*03 heterozygote genotype frequency (19% primary SS vs 3.5% controls; p<0.0006, OR=6.49) and especially for the HLA-DRBI*1501-*0301 genotype (16.7% primary SS vs 3% controls; p<0.002, OR=6.47). The DQB1*0201-*0602 genotype was also significantly increased in primary SS (17.1% primary SS vs 4% controls; p<0.006, OR=4.86). However, the higher risk to primary SS development was associated with the DRB1*1501-*0301 genotype (OR=6.47 vs 4.86). There were no differences between patients and controls in DPB1* allele frequencies. The HLA-DRB1*15-*03 heterozygote genotype was also associated with systemic features such as hematologic manifestations and Raynaud's phenomenon (RP) and with autoantibody production such as antinuclear, anti-Ro(SSA) or La(SSB) autoantibodies and rheumatoid factor. CONCLUSION: Our data suggest a role of the HLA-DRB1*1501-*0301 heterozygote genotype in susceptibility to primary SS. Moreover, the HLA-DRB1*1501-*0301 genotype was also found to be associated with a particular form of the disease characterized by RP, hematologic manifestations, and autoantibody production. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/9598888/Primary_Sjögren's_syndrome:_role_of_the_HLA_DRB1_0301__1501_heterozygotes_ L2 - https://medlineplus.gov/sjogrenssyndrome.html DB - PRIME DP - Unbound Medicine ER -