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Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.
J Neuropathol Exp Neurol. 1998 Apr; 57(4):334-7.JN

Abstract

A mutation in the alpha-synuclein gene has recently been linked to some cases of familial Parkinson's disease (PD). We characterized the expression of this presynaptic protein in the midbrain, striatum, and temporal cortex of control, PD, and dementia with Lewy bodies (DLB) brain. Control brain showed punctate pericellular immunostaining. PD brain demonstrated alpha-synuclein immunoreactivity in nigral Lewy bodies, pale bodies and abnormal neurites. Rare neuronal soma in PD brain were immunoreactive for alpha-synuclein. DLB cases demonstrated these findings as well as alpha-synuclein immunoreactivity in cortical Lewy bodies and CA2-3 neurites. These results suggest that, even in sporadic cases, there is an early and direct role for alpha-synuclein in the pathogenesis of PD and the neuropathologically related disorder DLB.

Authors+Show Affiliations

Alzheimer's Disease Research Unit, Massachusetts General Hospital-East, Charlestown 02129, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9600226

Citation

Irizarry, M C., et al. "Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinson's Disease and Cortical Lewy Body Disease Contain Alpha-synuclein Immunoreactivity." Journal of Neuropathology and Experimental Neurology, vol. 57, no. 4, 1998, pp. 334-7.
Irizarry MC, Growdon W, Gomez-Isla T, et al. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol. 1998;57(4):334-7.
Irizarry, M. C., Growdon, W., Gomez-Isla, T., Newell, K., George, J. M., Clayton, D. F., & Hyman, B. T. (1998). Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. Journal of Neuropathology and Experimental Neurology, 57(4), 334-7.
Irizarry MC, et al. Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinson's Disease and Cortical Lewy Body Disease Contain Alpha-synuclein Immunoreactivity. J Neuropathol Exp Neurol. 1998;57(4):334-7. PubMed PMID: 9600226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. AU - Irizarry,M C, AU - Growdon,W, AU - Gomez-Isla,T, AU - Newell,K, AU - George,J M, AU - Clayton,D F, AU - Hyman,B T, PY - 1998/5/26/pubmed PY - 1998/5/26/medline PY - 1998/5/26/entrez SP - 334 EP - 7 JF - Journal of neuropathology and experimental neurology JO - J Neuropathol Exp Neurol VL - 57 IS - 4 N2 - A mutation in the alpha-synuclein gene has recently been linked to some cases of familial Parkinson's disease (PD). We characterized the expression of this presynaptic protein in the midbrain, striatum, and temporal cortex of control, PD, and dementia with Lewy bodies (DLB) brain. Control brain showed punctate pericellular immunostaining. PD brain demonstrated alpha-synuclein immunoreactivity in nigral Lewy bodies, pale bodies and abnormal neurites. Rare neuronal soma in PD brain were immunoreactive for alpha-synuclein. DLB cases demonstrated these findings as well as alpha-synuclein immunoreactivity in cortical Lewy bodies and CA2-3 neurites. These results suggest that, even in sporadic cases, there is an early and direct role for alpha-synuclein in the pathogenesis of PD and the neuropathologically related disorder DLB. SN - 0022-3069 UR - https://www.unboundmedicine.com/medline/citation/9600226/Nigral_and_cortical_Lewy_bodies_and_dystrophic_nigral_neurites_in_Parkinson's_disease_and_cortical_Lewy_body_disease_contain_alpha_synuclein_immunoreactivity_ L2 - https://academic.oup.com/jnen/article-lookup/doi/10.1097/00005072-199804000-00005 DB - PRIME DP - Unbound Medicine ER -