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The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study.
J Allergy Clin Immunol. 1998 May; 101(5):587-93.JA

Abstract

OBJECTIVES

A birth cohort was followed-up to age 4 years to record the development of allergic disorders and to study the influence of genetic and environmental factors.

METHODS

Information on family history and environmental factors was obtained at birth, and serum cord IgE was measured. At age 4 years, 1218 children were reviewed.

RESULTS

By age 4 years, 27% of the children had symptoms of allergic disease. Period prevalence of asthma increased from 8.7% in infancy to 14.9% at 4 years. Family history of atopy was the single most important risk factor for atopy in children. Sibling atopy was a stronger predictor of clinical disease than maternal or paternal atopy, whereas paternal atopy, male sex, and high cord IgE were significant for the development of allergen sensitization. Children of asthmatic mothers were three times more likely to have asthma (odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.6-5.8) and rhinitis (OR: 2.9, CI: 1.1-7.4). Formula feeding before 3 months of age predisposed to asthma at age 4 years (OR: 1.8, CI: 1.2-2.6). The effect of maternal smoking on childhood wheeze seen at 1 and 2 years was lost by age 4, except for a subgroup with negative skin test responses (nonatopic asthma). Less than half (46%) of the infantile wheezers were still wheezing at 4 years of age.

CONCLUSION

Family history of atopy remains the most important risk factor for atopy in children, but other markers can be identified with a potential for intervention at an early age.

Authors+Show Affiliations

David Hide Asthma & Allergy Research Centre, St. Mary's Hospital, Newport, Isle of Wight, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9600493

Citation

Tariq, S M., et al. "The Prevalence of and Risk Factors for Atopy in Early Childhood: a Whole Population Birth Cohort Study." The Journal of Allergy and Clinical Immunology, vol. 101, no. 5, 1998, pp. 587-93.
Tariq SM, Matthews SM, Hakim EA, et al. The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. J Allergy Clin Immunol. 1998;101(5):587-93.
Tariq, S. M., Matthews, S. M., Hakim, E. A., Stevens, M., Arshad, S. H., & Hide, D. W. (1998). The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. The Journal of Allergy and Clinical Immunology, 101(5), 587-93.
Tariq SM, et al. The Prevalence of and Risk Factors for Atopy in Early Childhood: a Whole Population Birth Cohort Study. J Allergy Clin Immunol. 1998;101(5):587-93. PubMed PMID: 9600493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. AU - Tariq,S M, AU - Matthews,S M, AU - Hakim,E A, AU - Stevens,M, AU - Arshad,S H, AU - Hide,D W, PY - 1998/5/26/pubmed PY - 1998/5/26/medline PY - 1998/5/26/entrez SP - 587 EP - 93 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 101 IS - 5 N2 - OBJECTIVES: A birth cohort was followed-up to age 4 years to record the development of allergic disorders and to study the influence of genetic and environmental factors. METHODS: Information on family history and environmental factors was obtained at birth, and serum cord IgE was measured. At age 4 years, 1218 children were reviewed. RESULTS: By age 4 years, 27% of the children had symptoms of allergic disease. Period prevalence of asthma increased from 8.7% in infancy to 14.9% at 4 years. Family history of atopy was the single most important risk factor for atopy in children. Sibling atopy was a stronger predictor of clinical disease than maternal or paternal atopy, whereas paternal atopy, male sex, and high cord IgE were significant for the development of allergen sensitization. Children of asthmatic mothers were three times more likely to have asthma (odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.6-5.8) and rhinitis (OR: 2.9, CI: 1.1-7.4). Formula feeding before 3 months of age predisposed to asthma at age 4 years (OR: 1.8, CI: 1.2-2.6). The effect of maternal smoking on childhood wheeze seen at 1 and 2 years was lost by age 4, except for a subgroup with negative skin test responses (nonatopic asthma). Less than half (46%) of the infantile wheezers were still wheezing at 4 years of age. CONCLUSION: Family history of atopy remains the most important risk factor for atopy in children, but other markers can be identified with a potential for intervention at an early age. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/9600493/The_prevalence_of_and_risk_factors_for_atopy_in_early_childhood:_a_whole_population_birth_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(98)70164-2 DB - PRIME DP - Unbound Medicine ER -