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Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: results of a Canadian collaborative study. Investigators of the Canadian Pediatric Kidney Disease Research Center.
J Pediatr. 1998 May; 132(5):777-82.JPed

Abstract

OBJECTIVES

The objectives of this study were to better estimate the age-specific risks of hemolytic uremic syndrome (HUS) and hemolytic anemia after Escherichia coli O157:H7 infection among a representative cohort of both referred and nonreferred children with documented illness from the province of Alberta and to compare this with the rates in children evaluated at referral centers in the rest of Canada.

STUDY DESIGN

Children with HUS or E. coli O157:H7 gastroenteritis were eligible if they were < 15 years of age. Hemoglobin, blood smear, urinalysis, and serum creatinine were obtained 8 to 10 days after the onset of diarrhea to ascertain for hemolysis, anemia, thrombocytopenia, and renal injury. Subjects were monitored for 1 month.

RESULTS

From June 1991 to March 1994, HUS was diagnosed in 205 children. Of these 77% had evidence of E. coli O157:H7 infection. A further 582 children had E. coli O157:H7 gastroenteritis, of whom 18 had hemolytic anemia. The risk of HUS after E. coli O157:H7 infection in Alberta was 8.1% (95% confidence interval, 5.3 to 11.6) compared with 31.4% in referral centers in the rest of Canada. In Alberta the highest age-specific risk of HUS/hemolytic anemia was 12.9% in those < 5 years of age.

CONCLUSIONS

These data will help guide clinical care and provide a basis for estimating the sample sizes required in future treatment trials for the secondary prevention of HUS.

Authors+Show Affiliations

Canadian Pediatric Kidney Disease Research Center, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9602185

Citation

Rowe, P C., et al. "Risk of Hemolytic Uremic Syndrome After Sporadic Escherichia Coli O157:H7 Infection: Results of a Canadian Collaborative Study. Investigators of the Canadian Pediatric Kidney Disease Research Center." The Journal of Pediatrics, vol. 132, no. 5, 1998, pp. 777-82.
Rowe PC, Orrbine E, Lior H, et al. Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: results of a Canadian collaborative study. Investigators of the Canadian Pediatric Kidney Disease Research Center. J Pediatr. 1998;132(5):777-82.
Rowe, P. C., Orrbine, E., Lior, H., Wells, G. A., Yetisir, E., Clulow, M., & McLaine, P. N. (1998). Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: results of a Canadian collaborative study. Investigators of the Canadian Pediatric Kidney Disease Research Center. The Journal of Pediatrics, 132(5), 777-82.
Rowe PC, et al. Risk of Hemolytic Uremic Syndrome After Sporadic Escherichia Coli O157:H7 Infection: Results of a Canadian Collaborative Study. Investigators of the Canadian Pediatric Kidney Disease Research Center. J Pediatr. 1998;132(5):777-82. PubMed PMID: 9602185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: results of a Canadian collaborative study. Investigators of the Canadian Pediatric Kidney Disease Research Center. AU - Rowe,P C, AU - Orrbine,E, AU - Lior,H, AU - Wells,G A, AU - Yetisir,E, AU - Clulow,M, AU - McLaine,P N, PY - 1998/5/29/pubmed PY - 1998/5/29/medline PY - 1998/5/29/entrez SP - 777 EP - 82 JF - The Journal of pediatrics JO - J. Pediatr. VL - 132 IS - 5 N2 - OBJECTIVES: The objectives of this study were to better estimate the age-specific risks of hemolytic uremic syndrome (HUS) and hemolytic anemia after Escherichia coli O157:H7 infection among a representative cohort of both referred and nonreferred children with documented illness from the province of Alberta and to compare this with the rates in children evaluated at referral centers in the rest of Canada. STUDY DESIGN: Children with HUS or E. coli O157:H7 gastroenteritis were eligible if they were < 15 years of age. Hemoglobin, blood smear, urinalysis, and serum creatinine were obtained 8 to 10 days after the onset of diarrhea to ascertain for hemolysis, anemia, thrombocytopenia, and renal injury. Subjects were monitored for 1 month. RESULTS: From June 1991 to March 1994, HUS was diagnosed in 205 children. Of these 77% had evidence of E. coli O157:H7 infection. A further 582 children had E. coli O157:H7 gastroenteritis, of whom 18 had hemolytic anemia. The risk of HUS after E. coli O157:H7 infection in Alberta was 8.1% (95% confidence interval, 5.3 to 11.6) compared with 31.4% in referral centers in the rest of Canada. In Alberta the highest age-specific risk of HUS/hemolytic anemia was 12.9% in those < 5 years of age. CONCLUSIONS: These data will help guide clinical care and provide a basis for estimating the sample sizes required in future treatment trials for the secondary prevention of HUS. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/9602185/Risk_of_hemolytic_uremic_syndrome_after_sporadic_Escherichia_coli_O157:H7_infection:_results_of_a_Canadian_collaborative_study__Investigators_of_the_Canadian_Pediatric_Kidney_Disease_Research_Center_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022347698002170 DB - PRIME DP - Unbound Medicine ER -