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RETRACTED ARTICLE

Prevention of postoperative nausea and vomiting in female patients during menstruation: comparison of droperidol, metoclopramide and granisetron.
Br J Anaesth. 1998 Feb; 80(2):248-9.BJ

Abstract

The incidence of postoperative nausea and vomiting (PONV) is high in women during menstruation. We have compared the efficacy of droperidol, metoclopramide and granisetron in the prevention of PONV in female patients during menstruation undergoing major gynaecological surgery. In a randomized, double-blind study, 120 patients received droperidol 25 micrograms kg-1, metoclopramide 0.2 mg kg-1 or granisetron 40 micrograms kg-1 (n = 40 in each group) i.v. immediately before induction of anaesthesia. A standard general anaesthetic technique and postoperative analgesia were used throughout. There was a complete response, defined as no PONV and no administration of rescue medication, during the 24-h observation period in 45% of patients in the droperidol group, 38% in the metoclopramide group and 70% in the granisetron group (P = 0.021 vs droperidol, P = 0.003 vs metoclopramide). There was no difference in the incidence of adverse events between groups. We conclude that the prophylactic antiemetic efficacy of granisetron was superior to that of droperidol or metoclopramide for prevention of PONV in women during menstruation.

Authors+Show Affiliations

Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9602596

Citation

Fujii, Y, et al. "Prevention of Postoperative Nausea and Vomiting in Female Patients During Menstruation: Comparison of Droperidol, Metoclopramide and Granisetron." British Journal of Anaesthesia, vol. 80, no. 2, 1998, pp. 248-9.
Fujii Y, Toyooka H, Tanaka H. Prevention of postoperative nausea and vomiting in female patients during menstruation: comparison of droperidol, metoclopramide and granisetron. Br J Anaesth. 1998;80(2):248-9.
Fujii, Y., Toyooka, H., & Tanaka, H. (1998). Prevention of postoperative nausea and vomiting in female patients during menstruation: comparison of droperidol, metoclopramide and granisetron. British Journal of Anaesthesia, 80(2), 248-9.
Fujii Y, Toyooka H, Tanaka H. Prevention of Postoperative Nausea and Vomiting in Female Patients During Menstruation: Comparison of Droperidol, Metoclopramide and Granisetron. Br J Anaesth. 1998;80(2):248-9. PubMed PMID: 9602596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of postoperative nausea and vomiting in female patients during menstruation: comparison of droperidol, metoclopramide and granisetron. AU - Fujii,Y, AU - Toyooka,H, AU - Tanaka,H, PY - 1998/5/29/pubmed PY - 1998/5/29/medline PY - 1998/5/29/entrez SP - 248 EP - 9 JF - British journal of anaesthesia JO - Br J Anaesth VL - 80 IS - 2 N2 - The incidence of postoperative nausea and vomiting (PONV) is high in women during menstruation. We have compared the efficacy of droperidol, metoclopramide and granisetron in the prevention of PONV in female patients during menstruation undergoing major gynaecological surgery. In a randomized, double-blind study, 120 patients received droperidol 25 micrograms kg-1, metoclopramide 0.2 mg kg-1 or granisetron 40 micrograms kg-1 (n = 40 in each group) i.v. immediately before induction of anaesthesia. A standard general anaesthetic technique and postoperative analgesia were used throughout. There was a complete response, defined as no PONV and no administration of rescue medication, during the 24-h observation period in 45% of patients in the droperidol group, 38% in the metoclopramide group and 70% in the granisetron group (P = 0.021 vs droperidol, P = 0.003 vs metoclopramide). There was no difference in the incidence of adverse events between groups. We conclude that the prophylactic antiemetic efficacy of granisetron was superior to that of droperidol or metoclopramide for prevention of PONV in women during menstruation. SN - 0007-0912 UR - https://www.unboundmedicine.com/medline/citation/9602596/Prevention_of_postoperative_nausea_and_vomiting_in_female_patients_during_menstruation:_comparison_of_droperidol_metoclopramide_and_granisetron_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)40552-6 DB - PRIME DP - Unbound Medicine ER -