Tags

Type your tag names separated by a space and hit enter

Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique.
J Microencapsul. 1998 May-Jun; 15(3):319-33.JM

Abstract

Chitosan microspheres were prepared using an emulsification-coacervation technique. The w/o emulsion comprised a mixture of light and heavy liquid paraffins containing sodium dioctyl sulphosuccinate as the oil phase and chitosan solution as the aqueous phase. Pentasodium tripolyphosphate was included as a counterion. The chitosan microspheres obtained showed a high degree of aggregation. This was markedly reduced, by the incorporation of magnesium stearate in the disperse phase. The resultant microspheres were then discrete, spherical with smooth surfaces. Additionally, with an increasing magnesium stearate content, larger-sized microspheres were produced. The DSC analysis data suggested that the magnesium stearate was converted to stearic acid during the preparation process. Chitosan microspheres containing propranolol hydrochloride were similarly prepared, but their surface was convoluted and their shape not well defined. Unlike the microspheres without drug, the size of the drug-loaded microspheres decreased with increasing magnesium stearate content. The release of propranolol hydrochloride from the microspheres was fast, irrespective of the content of magnesium stearate. Drug encapsulation efficiency was enhanced when a greater amount of magnesium stearate was used.

Authors+Show Affiliations

Department of Pharmacy, National University of Singapore, Kent Ridge Crescent, Singapore.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9608395

Citation

Lim, L Y., and L S. Wan. "Effect of Magnesium Stearate On Chitosan Microspheres Prepared By an Emulsification-coacervation Technique." Journal of Microencapsulation, vol. 15, no. 3, 1998, pp. 319-33.
Lim LY, Wan LS. Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique. J Microencapsul. 1998;15(3):319-33.
Lim, L. Y., & Wan, L. S. (1998). Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique. Journal of Microencapsulation, 15(3), 319-33.
Lim LY, Wan LS. Effect of Magnesium Stearate On Chitosan Microspheres Prepared By an Emulsification-coacervation Technique. J Microencapsul. 1998 May-Jun;15(3):319-33. PubMed PMID: 9608395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique. AU - Lim,L Y, AU - Wan,L S, PY - 1998/6/3/pubmed PY - 1998/6/3/medline PY - 1998/6/3/entrez SP - 319 EP - 33 JF - Journal of microencapsulation JO - J Microencapsul VL - 15 IS - 3 N2 - Chitosan microspheres were prepared using an emulsification-coacervation technique. The w/o emulsion comprised a mixture of light and heavy liquid paraffins containing sodium dioctyl sulphosuccinate as the oil phase and chitosan solution as the aqueous phase. Pentasodium tripolyphosphate was included as a counterion. The chitosan microspheres obtained showed a high degree of aggregation. This was markedly reduced, by the incorporation of magnesium stearate in the disperse phase. The resultant microspheres were then discrete, spherical with smooth surfaces. Additionally, with an increasing magnesium stearate content, larger-sized microspheres were produced. The DSC analysis data suggested that the magnesium stearate was converted to stearic acid during the preparation process. Chitosan microspheres containing propranolol hydrochloride were similarly prepared, but their surface was convoluted and their shape not well defined. Unlike the microspheres without drug, the size of the drug-loaded microspheres decreased with increasing magnesium stearate content. The release of propranolol hydrochloride from the microspheres was fast, irrespective of the content of magnesium stearate. Drug encapsulation efficiency was enhanced when a greater amount of magnesium stearate was used. SN - 0265-2048 UR - https://www.unboundmedicine.com/medline/citation/9608395/Effect_of_magnesium_stearate_on_chitosan_microspheres_prepared_by_an_emulsification_coacervation_technique_ L2 - https://www.tandfonline.com/doi/full/10.3109/02652049809006860 DB - PRIME DP - Unbound Medicine ER -