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Successful treatment of retractile mesenteritis with oral progesterone.
Gastroenterology. 1998 Jun; 114(6):1313-7.G

Abstract

Retractile mesenteritis is a rare inflammatory mesenteric disorder that involves the intestine secondarily. The natural history of this process is diverse, but most patients require some empiric therapeutic measures. Up to now, pharmacological therapy has included corticosteroids, colchicine, and immunosuppressive drugs. Although these drugs are successful in most patients, some have been refractory to these therapies and, in others, the beneficial effects were counterbalanced by adverse reactions. Many patients require surgery, but most have poor results. This report describes a 42-year-old man with histologically proven retractile mesenteritis refractory to surgical intervention who had a good response to oral progesterone (10 mg/day for 6 months) with complete disappearance of tumor mass and clinical symptoms. No adverse effects were detected. Current knowledge about the mechanism by which progesterone affects fibrogenesis is scanty. It seems likely that progesterone down-regulates proliferation and metabolism of fibroblasts and fibrogenesis.

Authors+Show Affiliations

Clinical Department, Hospital de Gastroenterologia, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

9609769

Citation

Mazure, R, et al. "Successful Treatment of Retractile Mesenteritis With Oral Progesterone." Gastroenterology, vol. 114, no. 6, 1998, pp. 1313-7.
Mazure R, Fernandez Marty P, Niveloni S, et al. Successful treatment of retractile mesenteritis with oral progesterone. Gastroenterology. 1998;114(6):1313-7.
Mazure, R., Fernandez Marty, P., Niveloni, S., Pedreira, S., Vazquez, H., Smecuol, E., Kogan, Z., Boerr, L., Mauriño, E., & Bai, J. C. (1998). Successful treatment of retractile mesenteritis with oral progesterone. Gastroenterology, 114(6), 1313-7.
Mazure R, et al. Successful Treatment of Retractile Mesenteritis With Oral Progesterone. Gastroenterology. 1998;114(6):1313-7. PubMed PMID: 9609769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of retractile mesenteritis with oral progesterone. AU - Mazure,R, AU - Fernandez Marty,P, AU - Niveloni,S, AU - Pedreira,S, AU - Vazquez,H, AU - Smecuol,E, AU - Kogan,Z, AU - Boerr,L, AU - Mauriño,E, AU - Bai,J C, PY - 1998/6/3/pubmed PY - 1998/6/3/medline PY - 1998/6/3/entrez SP - 1313 EP - 7 JF - Gastroenterology JO - Gastroenterology VL - 114 IS - 6 N2 - Retractile mesenteritis is a rare inflammatory mesenteric disorder that involves the intestine secondarily. The natural history of this process is diverse, but most patients require some empiric therapeutic measures. Up to now, pharmacological therapy has included corticosteroids, colchicine, and immunosuppressive drugs. Although these drugs are successful in most patients, some have been refractory to these therapies and, in others, the beneficial effects were counterbalanced by adverse reactions. Many patients require surgery, but most have poor results. This report describes a 42-year-old man with histologically proven retractile mesenteritis refractory to surgical intervention who had a good response to oral progesterone (10 mg/day for 6 months) with complete disappearance of tumor mass and clinical symptoms. No adverse effects were detected. Current knowledge about the mechanism by which progesterone affects fibrogenesis is scanty. It seems likely that progesterone down-regulates proliferation and metabolism of fibroblasts and fibrogenesis. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/9609769/Successful_treatment_of_retractile_mesenteritis_with_oral_progesterone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508598005575 DB - PRIME DP - Unbound Medicine ER -