Tags

Type your tag names separated by a space and hit enter

[Determination of prostate-specific antigen (PSA) in cytosol of breast tumors and human endometrium--new diagnostic approaches].
Zentralbl Gynakol. 1998; 120(4):172-5.ZG

Abstract

Prostate specific antigen is a highly specific marker of prostatic tissue. Recent studies have shown, that it is present in several other human tissues, tumors and fluids. PSA has been identified as a serine protease and member of the kallikrein family of enzymes. In our study PSA concentration was measured in 97 cytosols of breast cancer tissues and 14 samples, prepared from human endometrium. Cytosols were analysed also for steroid hormone receptors, EGF-receptor, Cathepsin D and pS-2 protein. PSA was found in 84.5% of breast cancer tissues and in 12 endometrium samples. High concentration of PSA were associated with high pS-2 protein levels. No correlation was found between the concentration of steroid hormone receptors and PSA in our material. The results suggest, that PSA in cytosol of human breast cancer and endometrial tissues may be an additional new prognostic indicator.

Authors+Show Affiliations

Klinik und Poliklinik für Geburtshilfe und Reproduktionsmedizin, Martin-Luther-Universität Halle-Wittenberg.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

9610520

Citation

Seliger, E, et al. "[Determination of Prostate-specific Antigen (PSA) in Cytosol of Breast Tumors and Human Endometrium--new Diagnostic Approaches]." Zentralblatt Fur Gynakologie, vol. 120, no. 4, 1998, pp. 172-5.
Seliger E, Kaltwasser P, Röpke F. [Determination of prostate-specific antigen (PSA) in cytosol of breast tumors and human endometrium--new diagnostic approaches]. Zentralbl Gynakol. 1998;120(4):172-5.
Seliger, E., Kaltwasser, P., & Röpke, F. (1998). [Determination of prostate-specific antigen (PSA) in cytosol of breast tumors and human endometrium--new diagnostic approaches]. Zentralblatt Fur Gynakologie, 120(4), 172-5.
Seliger E, Kaltwasser P, Röpke F. [Determination of Prostate-specific Antigen (PSA) in Cytosol of Breast Tumors and Human Endometrium--new Diagnostic Approaches]. Zentralbl Gynakol. 1998;120(4):172-5. PubMed PMID: 9610520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination of prostate-specific antigen (PSA) in cytosol of breast tumors and human endometrium--new diagnostic approaches]. AU - Seliger,E, AU - Kaltwasser,P, AU - Röpke,F, PY - 1998/6/4/pubmed PY - 1998/6/4/medline PY - 1998/6/4/entrez SP - 172 EP - 5 JF - Zentralblatt fur Gynakologie JO - Zentralbl Gynakol VL - 120 IS - 4 N2 - Prostate specific antigen is a highly specific marker of prostatic tissue. Recent studies have shown, that it is present in several other human tissues, tumors and fluids. PSA has been identified as a serine protease and member of the kallikrein family of enzymes. In our study PSA concentration was measured in 97 cytosols of breast cancer tissues and 14 samples, prepared from human endometrium. Cytosols were analysed also for steroid hormone receptors, EGF-receptor, Cathepsin D and pS-2 protein. PSA was found in 84.5% of breast cancer tissues and in 12 endometrium samples. High concentration of PSA were associated with high pS-2 protein levels. No correlation was found between the concentration of steroid hormone receptors and PSA in our material. The results suggest, that PSA in cytosol of human breast cancer and endometrial tissues may be an additional new prognostic indicator. SN - 0044-4197 UR - https://www.unboundmedicine.com/medline/citation/9610520/[Determination_of_prostate_specific_antigen__PSA__in_cytosol_of_breast_tumors_and_human_endometrium__new_diagnostic_approaches]_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -