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[Serum HRP-2 antigens and imported Plasmodium falciparum malaria: comparison of ParaSight-F and ICT malaria P.f].
Med Trop (Mars). 1997; 57(4):353-6.MT

Abstract

Serum levels of HRP-2 antigens against Plasmodium falciparum in 568 venous blood samples collected at two general hospitals were evaluated using the ParaSight-F (Becton-Dickinson) alone (568/568 samples) or in combination (156/568 samples) with the new ICT-Malaria P.f. (ICT-diagnostic). Comparison with the reference method (thin and thick blood smears assessed by two experienced parasitologists) showed that both tests were highly sensitive (93% and 96% respectively) and specific (98% and 98% respectively). The positive predictive values of the two tests were equal (96%) and the negative predicative values were close (96% and 98% respectively). Although both tests provided results within 10 minutes and required no special equipment for interpretation, the ICT-Malaria P.f. test seemed simpler and easier to use than the ParaSight-F test. The ParaSight-F test alone was used to monitor serum antigen levels after treatment in 24 patients. Antigen levels remained positive for at least three days after disappearance of circulating parasites (range: 3 to 28 days). Evaluation of serum levels of HRP-2 antigens can be useful for emergency diagnosis, especially in patients with low circulating parasite levels. The ICT-Malaria P.f. test seems especially suited for in-field use.

Authors+Show Affiliations

Cavallo JD
Laboratoire de Biologie, l'Hôpital d'Instruction des Armées Bégin, Saint Mandé, France.
Hernandez E
No affiliation info available
Gerome P
No affiliation info available
Plotton N
No affiliation info available
Debord T
No affiliation info available
Le Vagueresse R
No affiliation info available

MeSH

AnimalsAntigens, ProtozoanHumansMalariaMalaria, FalciparumMalaria, VivaxMilitary PersonnelPlasmodiumPlasmodium falciparumPlasmodium vivaxPredictive Value of TestsProspective StudiesProteinsReagent Kits, DiagnosticSensitivity and Specificity

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

fre

PubMed ID

9612775

Citation

Cavallo, J D., et al. "[Serum HRP-2 Antigens and Imported Plasmodium Falciparum Malaria: Comparison of ParaSight-F and ICT Malaria P.f]." Medecine Tropicale : Revue Du Corps De Sante Colonial, vol. 57, no. 4, 1997, pp. 353-6.
Cavallo JD, Hernandez E, Gerome P, et al. [Serum HRP-2 antigens and imported Plasmodium falciparum malaria: comparison of ParaSight-F and ICT malaria P.f]. Med Trop (Mars). 1997;57(4):353-6.
Cavallo, J. D., Hernandez, E., Gerome, P., Plotton, N., Debord, T., & Le Vagueresse, R. (1997). [Serum HRP-2 antigens and imported Plasmodium falciparum malaria: comparison of ParaSight-F and ICT malaria P.f]. Medecine Tropicale : Revue Du Corps De Sante Colonial, 57(4), 353-6.
Cavallo JD, et al. [Serum HRP-2 Antigens and Imported Plasmodium Falciparum Malaria: Comparison of ParaSight-F and ICT Malaria P.f]. Med Trop (Mars). 1997;57(4):353-6. PubMed PMID: 9612775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum HRP-2 antigens and imported Plasmodium falciparum malaria: comparison of ParaSight-F and ICT malaria P.f]. AU - Cavallo,J D, AU - Hernandez,E, AU - Gerome,P, AU - Plotton,N, AU - Debord,T, AU - Le Vagueresse,R, PY - 1997/1/1/pubmed PY - 1998/6/5/medline PY - 1997/1/1/entrez SP - 353 EP - 6 JF - Medecine tropicale : revue du Corps de sante colonial JO - Med Trop (Mars) VL - 57 IS - 4 N2 - Serum levels of HRP-2 antigens against Plasmodium falciparum in 568 venous blood samples collected at two general hospitals were evaluated using the ParaSight-F (Becton-Dickinson) alone (568/568 samples) or in combination (156/568 samples) with the new ICT-Malaria P.f. (ICT-diagnostic). Comparison with the reference method (thin and thick blood smears assessed by two experienced parasitologists) showed that both tests were highly sensitive (93% and 96% respectively) and specific (98% and 98% respectively). The positive predictive values of the two tests were equal (96%) and the negative predicative values were close (96% and 98% respectively). Although both tests provided results within 10 minutes and required no special equipment for interpretation, the ICT-Malaria P.f. test seemed simpler and easier to use than the ParaSight-F test. The ParaSight-F test alone was used to monitor serum antigen levels after treatment in 24 patients. Antigen levels remained positive for at least three days after disappearance of circulating parasites (range: 3 to 28 days). Evaluation of serum levels of HRP-2 antigens can be useful for emergency diagnosis, especially in patients with low circulating parasite levels. The ICT-Malaria P.f. test seems especially suited for in-field use. SN - 0025-682X UR - https://www.unboundmedicine.com/medline/citation/9612775/[Serum_HRP_2_antigens_and_imported_Plasmodium_falciparum_malaria:_comparison_of_ParaSight_F_and_ICT_malaria_P_f]_ DB - PRIME DP - Unbound Medicine ER -