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Iron metabolism and Parkinson's disease.
Mov Disord. 1998; 13 Suppl 1:39-45.MD

Abstract

There are at least three major reasons for thinking that iron participates in the mechanism of nerve cell death in Parkinson's disease (PD): (1) Iron catalyzes the formation of highly toxic hydroxyl radicals through the Fenton reaction. (2) Evidence suggests that oxidative stress participates in the mechanism of nerve cell death in PD. (3) Increased iron concentrations have been observed in the substantia nigra of patients with PD. In this review, we report data suggesting that the vulnerable neurons in PD are particularly sensitive to oxidative stress that may be induced by iron and then discuss the mechanisms by which iron levels may be increased in dopaminergic neurons in PD.

Authors+Show Affiliations

INSERM U289, Hôpital de la Salpêtrière, Paris, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

9613717

Citation

Hirsch, E C., and B A. Faucheux. "Iron Metabolism and Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 13 Suppl 1, 1998, pp. 39-45.
Hirsch EC, Faucheux BA. Iron metabolism and Parkinson's disease. Mov Disord. 1998;13 Suppl 1:39-45.
Hirsch, E. C., & Faucheux, B. A. (1998). Iron metabolism and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 13 Suppl 1, 39-45.
Hirsch EC, Faucheux BA. Iron Metabolism and Parkinson's Disease. Mov Disord. 1998;13 Suppl 1:39-45. PubMed PMID: 9613717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron metabolism and Parkinson's disease. AU - Hirsch,E C, AU - Faucheux,B A, PY - 1998/6/5/pubmed PY - 1998/6/5/medline PY - 1998/6/5/entrez SP - 39 EP - 45 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 13 Suppl 1 N2 - There are at least three major reasons for thinking that iron participates in the mechanism of nerve cell death in Parkinson's disease (PD): (1) Iron catalyzes the formation of highly toxic hydroxyl radicals through the Fenton reaction. (2) Evidence suggests that oxidative stress participates in the mechanism of nerve cell death in PD. (3) Increased iron concentrations have been observed in the substantia nigra of patients with PD. In this review, we report data suggesting that the vulnerable neurons in PD are particularly sensitive to oxidative stress that may be induced by iron and then discuss the mechanisms by which iron levels may be increased in dopaminergic neurons in PD. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/9613717/Iron_metabolism_and_Parkinson's_disease_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -