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Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography.
J Chromatogr B Biomed Sci Appl. 1998 Apr 10; 707(1-2):317-21.JC

Abstract

A high-performance liquid chromatographic method with diode-array detection for the determination of nicotine and its metabolites, cotinine and caffeine, in meconium is described. This method is suitable to assess foetus exposure to tobacco smoke. The analytes were extracted by solid-phase extraction before chromatography. From among 30 meconium samples 11 were positive for cotinine (20-86 ng/g) and 27 for caffeine (10-45 ng/g). No nicotine was present in the samples because of its rapid metabolism into cotinine.

Authors+Show Affiliations

Baranowski J
Neonatal Pathology Clinic, Silesian Medical University, Zabrze, Poland.
Pochopień G
No affiliation info available
Baranowska I
No affiliation info available

MeSH

AdultCaffeineCentral Nervous System StimulantsChromatography, High Pressure LiquidCotinineFemaleHumansInfant, NewbornMaternal-Fetal ExchangeMeconiumNicotineNicotinic AgonistsPregnancySmoking

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9613966

Citation

Baranowski, J, et al. "Determination of Nicotine, Cotinine and Caffeine in Meconium Using High-performance Liquid Chromatography." Journal of Chromatography. B, Biomedical Sciences and Applications, vol. 707, no. 1-2, 1998, pp. 317-21.
Baranowski J, Pochopień G, Baranowska I. Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998;707(1-2):317-21.
Baranowski, J., Pochopień, G., & Baranowska, I. (1998). Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications, 707(1-2), 317-21.
Baranowski J, Pochopień G, Baranowska I. Determination of Nicotine, Cotinine and Caffeine in Meconium Using High-performance Liquid Chromatography. J Chromatogr B Biomed Sci Appl. 1998 Apr 10;707(1-2):317-21. PubMed PMID: 9613966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography. AU - Baranowski,J, AU - Pochopień,G, AU - Baranowska,I, PY - 1998/6/5/pubmed PY - 1998/6/5/medline PY - 1998/6/5/entrez SP - 317 EP - 21 JF - Journal of chromatography. B, Biomedical sciences and applications JO - J Chromatogr B Biomed Sci Appl VL - 707 IS - 1-2 N2 - A high-performance liquid chromatographic method with diode-array detection for the determination of nicotine and its metabolites, cotinine and caffeine, in meconium is described. This method is suitable to assess foetus exposure to tobacco smoke. The analytes were extracted by solid-phase extraction before chromatography. From among 30 meconium samples 11 were positive for cotinine (20-86 ng/g) and 27 for caffeine (10-45 ng/g). No nicotine was present in the samples because of its rapid metabolism into cotinine. SN - 1387-2273 UR - https://www.unboundmedicine.com/medline/citation/9613966/Determination_of_nicotine_cotinine_and_caffeine_in_meconium_using_high_performance_liquid_chromatography_ L2 - https://medlineplus.gov/caffeine.html DB - PRIME DP - Unbound Medicine ER -