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A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali.
Bull World Health Organ. 1998; 76(1):63-71.BW

Abstract

Despite considerable experience with single-dose, live, oral cholera vaccine CVD 103-HgR in Asia, Europe, and the Americas, the vaccine had not been evaluated in sub-Saharan Africa or on individuals infected with human immunodeficiency virus (HIV). We therefore conducted a randomized, placebo-controlled, double-blind, cross-over clinical trial in 38 HIV-seropositive (without clinical acquired immunodeficiency syndrome (AIDS)) and 387 HIV-seronegative adults in Mali to assess its safety and immunogenicity. Adverse reactions (fever, diarrhoea and vomiting) were observed with similar frequency among vaccine and placebo recipients. The vaccine strain was not isolated from the coprocultures of any subject. The baseline geometric mean titre (GMT) of serum vibriocidal antibody was significantly lower in HIV-seropositives (1:23) than in HIV-seronegatives (1:65) (P = 0.002). Significant rises in vibriocidal antibody were observed in 71% of HIV-seronegatives and 58% of HIV-seropositives, and in 40% of HIV-seropositives with CD4+ counts below 500 per microliter. Following immunization, the peak vibriocidal GMT in HIV-seronegatives was 1:584 versus 1:124 in HIV-seropositives (P = 0.0006); in HIV-seropositives with CD4+ counts < 500 per microliter, the peak vibriocidal GMT was 1:40 (P = 0.03 versus other HIV-seropositives). CVD 103-HgR was safe in HIV-infected Malian adults, although serological responses were significantly attenuated among HIV-seropositives (particularly in those with CD4+ counts < 500 per microliter) relative to HIV-seronegatives. These results encourage further evaluations of this single-dose, oral cholera vaccine in high-risk populations such as refugees in sub-Saharan Africa.

Authors+Show Affiliations

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9615498

Citation

Perry, R T., et al. "A Single Dose of Live Oral Cholera Vaccine CVD 103-HgR Is Safe and Immunogenic in HIV-infected and HIV-noninfected Adults in Mali." Bulletin of the World Health Organization, vol. 76, no. 1, 1998, pp. 63-71.
Perry RT, Plowe CV, Koumaré B, et al. A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali. Bull World Health Organ. 1998;76(1):63-71.
Perry, R. T., Plowe, C. V., Koumaré, B., Bougoudogo, F., Kotloff, K. L., Losonsky, G. A., Wasserman, S. S., & Levine, M. M. (1998). A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali. Bulletin of the World Health Organization, 76(1), 63-71.
Perry RT, et al. A Single Dose of Live Oral Cholera Vaccine CVD 103-HgR Is Safe and Immunogenic in HIV-infected and HIV-noninfected Adults in Mali. Bull World Health Organ. 1998;76(1):63-71. PubMed PMID: 9615498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali. AU - Perry,R T, AU - Plowe,C V, AU - Koumaré,B, AU - Bougoudogo,F, AU - Kotloff,K L, AU - Losonsky,G A, AU - Wasserman,S S, AU - Levine,M M, PY - 1998/6/6/pubmed PY - 1998/6/6/medline PY - 1998/6/6/entrez KW - Acquired Immunodeficiency Syndrome KW - Africa KW - Africa South Of The Sahara KW - Bacterial And Fungal Diseases KW - Cholera--prevention and control KW - Clinical Research KW - Developing Countries KW - Diseases KW - French Speaking Africa KW - Hiv Infections KW - Infections KW - Mali KW - Research Methodology KW - Research Report KW - Vaccines KW - Viral Diseases KW - Western Africa SP - 63 EP - 71 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 76 IS - 1 N2 - Despite considerable experience with single-dose, live, oral cholera vaccine CVD 103-HgR in Asia, Europe, and the Americas, the vaccine had not been evaluated in sub-Saharan Africa or on individuals infected with human immunodeficiency virus (HIV). We therefore conducted a randomized, placebo-controlled, double-blind, cross-over clinical trial in 38 HIV-seropositive (without clinical acquired immunodeficiency syndrome (AIDS)) and 387 HIV-seronegative adults in Mali to assess its safety and immunogenicity. Adverse reactions (fever, diarrhoea and vomiting) were observed with similar frequency among vaccine and placebo recipients. The vaccine strain was not isolated from the coprocultures of any subject. The baseline geometric mean titre (GMT) of serum vibriocidal antibody was significantly lower in HIV-seropositives (1:23) than in HIV-seronegatives (1:65) (P = 0.002). Significant rises in vibriocidal antibody were observed in 71% of HIV-seronegatives and 58% of HIV-seropositives, and in 40% of HIV-seropositives with CD4+ counts below 500 per microliter. Following immunization, the peak vibriocidal GMT in HIV-seronegatives was 1:584 versus 1:124 in HIV-seropositives (P = 0.0006); in HIV-seropositives with CD4+ counts < 500 per microliter, the peak vibriocidal GMT was 1:40 (P = 0.03 versus other HIV-seropositives). CVD 103-HgR was safe in HIV-infected Malian adults, although serological responses were significantly attenuated among HIV-seropositives (particularly in those with CD4+ counts < 500 per microliter) relative to HIV-seronegatives. These results encourage further evaluations of this single-dose, oral cholera vaccine in high-risk populations such as refugees in sub-Saharan Africa. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/9615498/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9615498/ DB - PRIME DP - Unbound Medicine ER -