Tags

Type your tag names separated by a space and hit enter

Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus.
Neurobiol Learn Mem. 1998 Mar; 69(2):87-91.NL

Abstract

The purpose of the present research was to further evaluate the role of hippocampal N-methyl-D-aspartate (NMDA) receptors in inhibitory avoidance task consolidation. Adult male Wistar rats were trained and tested in a step-down inhibitory avoidance task (0.4 mA footshock, 24 h training-test interval). Immediately after training, animals received a 0.5-microl intrahippocampal infusion of the NMDA receptor antagonist aminophosphonopentanoic acid (AP5) (5.0 microg) or vehicle (phosphate buffer in saline, pH 7.4). The infusion of AP5 impaired retention test performance. Both pretraining with a low footshock intensity (0.2 mA) or preexposure to the inhibitory avoidance box 24 h before training prevented the amnestic effect of AP5. The results suggest that hippocampal NMDA receptors are critical for neither the enhancement of retention induced by an additional training session nor the inhibitory avoidance retention in animals that have previously learned about the task environment by preexposure to the apparatus.

Authors+Show Affiliations

Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul (Campus da Saude), Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9619989

Citation

Roesler, R, et al. "Intrahippocampal Infusion of the NMDA Receptor Antagonist AP5 Impairs Retention of an Inhibitory Avoidance Task: Protection From Impairment By Pretraining or Preexposure to the Task Apparatus." Neurobiology of Learning and Memory, vol. 69, no. 2, 1998, pp. 87-91.
Roesler R, Vianna M, Sant'Anna MK, et al. Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus. Neurobiol Learn Mem. 1998;69(2):87-91.
Roesler, R., Vianna, M., Sant'Anna, M. K., Kuyven, C. R., Kruel, A. V., Quevedo, J., & Ferreira, M. B. (1998). Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus. Neurobiology of Learning and Memory, 69(2), 87-91.
Roesler R, et al. Intrahippocampal Infusion of the NMDA Receptor Antagonist AP5 Impairs Retention of an Inhibitory Avoidance Task: Protection From Impairment By Pretraining or Preexposure to the Task Apparatus. Neurobiol Learn Mem. 1998;69(2):87-91. PubMed PMID: 9619989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus. AU - Roesler,R, AU - Vianna,M, AU - Sant'Anna,M K, AU - Kuyven,C R, AU - Kruel,A V, AU - Quevedo,J, AU - Ferreira,M B, PY - 1998/6/10/pubmed PY - 1998/6/10/medline PY - 1998/6/10/entrez SP - 87 EP - 91 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 69 IS - 2 N2 - The purpose of the present research was to further evaluate the role of hippocampal N-methyl-D-aspartate (NMDA) receptors in inhibitory avoidance task consolidation. Adult male Wistar rats were trained and tested in a step-down inhibitory avoidance task (0.4 mA footshock, 24 h training-test interval). Immediately after training, animals received a 0.5-microl intrahippocampal infusion of the NMDA receptor antagonist aminophosphonopentanoic acid (AP5) (5.0 microg) or vehicle (phosphate buffer in saline, pH 7.4). The infusion of AP5 impaired retention test performance. Both pretraining with a low footshock intensity (0.2 mA) or preexposure to the inhibitory avoidance box 24 h before training prevented the amnestic effect of AP5. The results suggest that hippocampal NMDA receptors are critical for neither the enhancement of retention induced by an additional training session nor the inhibitory avoidance retention in animals that have previously learned about the task environment by preexposure to the apparatus. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/9619989/Intrahippocampal_infusion_of_the_NMDA_receptor_antagonist_AP5_impairs_retention_of_an_inhibitory_avoidance_task:_protection_from_impairment_by_pretraining_or_preexposure_to_the_task_apparatus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(97)93810-7 DB - PRIME DP - Unbound Medicine ER -