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Periconceptional folic acid containing multivitamin supplementation.
Eur J Obstet Gynecol Reprod Biol. 1998 Jun; 78(2):151-61.EJ

Abstract

OBJECTIVE

A summary about the final results of the Hungarian double-blind placebo controlled randomised trial of periconceptional folic acid containing multivitamin and trace element supplementation.

RESULTS

The major finding is a significant prevention of the first occurrence of neural-tube defect, urinary tract and cardiovascular defects, in addition a decrease in the rate of limb deficiencies and congenital hypertrophic pyloric stenosis. Fertility was slightly improved and the rate of twins increased significantly after periconceptional multivitamin supplementation. The effect of multivitamin supplementation for fetal death is controversial, but in general there is no clinically significant change. Periconceptional multivitamin supplementation can reduce the occurrence of nausea and vomiting.

PRACTICAL IMPLEMENTATIONS

Consumption of foods which are rich in folate may not be the best way to prevent neural-tube defects and other congenital abnormalities. Periconceptional multivitamin supplementation is part of the periconceptional care in Hungary and it is an appropriate forum for the practical delivery for this primary prevention action. However, as a large proportion of pregnancies are unplanned, the widespread use of bread fortified with folic acid, vitamin B12 and B6 may decrease a considerable part of neural-tube defects and some other congenital abnormalities, in addition to vascular diseases due to hyperhomocysteinemia.

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Publisher Full Text

Authors+Show Affiliations

Czeizel AE
Department of Human Genetics and Teratology, National Institute of Public Health-WHO Collaborating Centre for the Community Control of Hereditary Diseases, OKI, Budapest, Hungary.

MeSH

AnimalsCongenital AbnormalitiesDietDietary SupplementsFemaleFertilizationFolic AcidFood, FortifiedHumansNeural Tube DefectsPregnancyVitamins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9622312

Citation

Czeizel, A E.. "Periconceptional Folic Acid Containing Multivitamin Supplementation." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 78, no. 2, 1998, pp. 151-61.
Czeizel AE. Periconceptional folic acid containing multivitamin supplementation. Eur J Obstet Gynecol Reprod Biol. 1998;78(2):151-61.
Czeizel, A. E. (1998). Periconceptional folic acid containing multivitamin supplementation. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 78(2), 151-61.
Czeizel AE. Periconceptional Folic Acid Containing Multivitamin Supplementation. Eur J Obstet Gynecol Reprod Biol. 1998;78(2):151-61. PubMed PMID: 9622312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periconceptional folic acid containing multivitamin supplementation. A1 - Czeizel,A E, PY - 1998/6/11/pubmed PY - 1998/6/11/medline PY - 1998/6/11/entrez SP - 151 EP - 61 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 78 IS - 2 N2 - OBJECTIVE: A summary about the final results of the Hungarian double-blind placebo controlled randomised trial of periconceptional folic acid containing multivitamin and trace element supplementation. RESULTS: The major finding is a significant prevention of the first occurrence of neural-tube defect, urinary tract and cardiovascular defects, in addition a decrease in the rate of limb deficiencies and congenital hypertrophic pyloric stenosis. Fertility was slightly improved and the rate of twins increased significantly after periconceptional multivitamin supplementation. The effect of multivitamin supplementation for fetal death is controversial, but in general there is no clinically significant change. Periconceptional multivitamin supplementation can reduce the occurrence of nausea and vomiting. PRACTICAL IMPLEMENTATIONS: Consumption of foods which are rich in folate may not be the best way to prevent neural-tube defects and other congenital abnormalities. Periconceptional multivitamin supplementation is part of the periconceptional care in Hungary and it is an appropriate forum for the practical delivery for this primary prevention action. However, as a large proportion of pregnancies are unplanned, the widespread use of bread fortified with folic acid, vitamin B12 and B6 may decrease a considerable part of neural-tube defects and some other congenital abnormalities, in addition to vascular diseases due to hyperhomocysteinemia. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/9622312/Periconceptional_folic_acid_containing_multivitamin_supplementation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S030121159800061X DB - PRIME DP - Unbound Medicine ER -