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Fine needle aspiration of mucinous (colloid) breast carcinoma. Nuclear grading and mammographic and cytologic findings.
Acta Cytol. 1998 May-Jun; 42(3):668-72.AC

Abstract

OBJECTIVE

The clinical, mammographic and low grade cytologic features of mucinous carcinoma can make it difficult to diagnose by fine needle aspiration (FNA). Fine needle aspirates of mucinous carcinoma were reviewed with the mammographic findings to improve the diagnostic criteria and specificity for FNA.

STUDY DESIGN

All aspirates were reviewed for cytologic criteria and cellularity, atypia and single epithelial cells (SEC). A nuclear grade was assigned to each aspirate. The mammographic findings were correlated with the FNA diagnoses.

RESULTS

Forty-five patients with an aspirate and confirmed diagnosis of mucinous carcinoma were identified. The clinical impressions were: benign tissue (5), fibroadenoma (6) and cancer (32). The initial cytologic diagnoses were: adenocarcinoma (32), atypical/suspicious for cancer (11), insufficient (1) and negative (1). The cytologic findings showed smears with increased cellularity (35/45 cases) and minimal atypia. SEC with eccentrically located nuclei and eosinophilic cytoplasm were numerous. The assigned nuclear grade was as follows: grade 1, 16 cases; grade 2, 20 cases; and grade 3, 6 cases. Abundant mucin was present in Papanicolaou-stained slides in 23 cases; focal mucin was observed in 14 cases. The mammograms showed a smoothly outlined to lobulated mass with only slight irregularities identified.

CONCLUSION

Mucinous carcinoma has a cytologic pattern that includes increased cellularity, with numerous single cells and abundant mucin. Although the mammographic findings may mimic a benign lesion, in the most patients a specific diagnosis of mucinous carcinoma can be made by FNA.

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Authors+Show Affiliations

Dawson AE
Department of Pathology, University of Rochester Medical Center, New York, USA.
Mulford DK
No affiliation info available

MeSH

Adenocarcinoma, MucinousAdultAgedAged, 80 and overBiopsy, NeedleBreast NeoplasmsCell NucleusDiagnosis, DifferentialEpithelial CellsFemaleFibroadenomaHumansMammographyMiddle AgedRetrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9622685

Citation

Dawson, A E., and D K. Mulford. "Fine Needle Aspiration of Mucinous (colloid) Breast Carcinoma. Nuclear Grading and Mammographic and Cytologic Findings." Acta Cytologica, vol. 42, no. 3, 1998, pp. 668-72.
Dawson AE, Mulford DK. Fine needle aspiration of mucinous (colloid) breast carcinoma. Nuclear grading and mammographic and cytologic findings. Acta Cytol. 1998;42(3):668-72.
Dawson, A. E., & Mulford, D. K. (1998). Fine needle aspiration of mucinous (colloid) breast carcinoma. Nuclear grading and mammographic and cytologic findings. Acta Cytologica, 42(3), 668-72.
Dawson AE, Mulford DK. Fine Needle Aspiration of Mucinous (colloid) Breast Carcinoma. Nuclear Grading and Mammographic and Cytologic Findings. Acta Cytol. 1998 May-Jun;42(3):668-72. PubMed PMID: 9622685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fine needle aspiration of mucinous (colloid) breast carcinoma. Nuclear grading and mammographic and cytologic findings. AU - Dawson,A E, AU - Mulford,D K, PY - 1998/6/12/pubmed PY - 1998/6/12/medline PY - 1998/6/12/entrez SP - 668 EP - 72 JF - Acta cytologica JO - Acta Cytol. VL - 42 IS - 3 N2 - OBJECTIVE: The clinical, mammographic and low grade cytologic features of mucinous carcinoma can make it difficult to diagnose by fine needle aspiration (FNA). Fine needle aspirates of mucinous carcinoma were reviewed with the mammographic findings to improve the diagnostic criteria and specificity for FNA. STUDY DESIGN: All aspirates were reviewed for cytologic criteria and cellularity, atypia and single epithelial cells (SEC). A nuclear grade was assigned to each aspirate. The mammographic findings were correlated with the FNA diagnoses. RESULTS: Forty-five patients with an aspirate and confirmed diagnosis of mucinous carcinoma were identified. The clinical impressions were: benign tissue (5), fibroadenoma (6) and cancer (32). The initial cytologic diagnoses were: adenocarcinoma (32), atypical/suspicious for cancer (11), insufficient (1) and negative (1). The cytologic findings showed smears with increased cellularity (35/45 cases) and minimal atypia. SEC with eccentrically located nuclei and eosinophilic cytoplasm were numerous. The assigned nuclear grade was as follows: grade 1, 16 cases; grade 2, 20 cases; and grade 3, 6 cases. Abundant mucin was present in Papanicolaou-stained slides in 23 cases; focal mucin was observed in 14 cases. The mammograms showed a smoothly outlined to lobulated mass with only slight irregularities identified. CONCLUSION: Mucinous carcinoma has a cytologic pattern that includes increased cellularity, with numerous single cells and abundant mucin. Although the mammographic findings may mimic a benign lesion, in the most patients a specific diagnosis of mucinous carcinoma can be made by FNA. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/9622685/Fine_needle_aspiration_of_mucinous__colloid__breast_carcinoma__Nuclear_grading_and_mammographic_and_cytologic_findings_ L2 - https://www.karger.com?DOI=10.1159/000331824 DB - PRIME DP - Unbound Medicine ER -