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The effect of dietary sodium intake on biochemical markers of bone metabolism in young women.

Abstract

To investigate the effect of a low (80 mmol/d) or high (180 mmol/d) Na intake for 14d on biochemical markers of bone turnover in Na-sensitive and Na-non-sensitive healthy young women, twenty-nine subjects were screened for responsiveness of urinary Ca excretion to increasing dietary Na intake (40, 80, 120 and 200 mmol/d for 7 d). In a crossover study, the eight Na-sensitive and eight of the twenty-one Na-non-sensitive subjects were randomly assigned to diets containing either 80 or 180 mmol Na/d for 14d followed by crossover to the alternative diet for a further 14 d. Dietary Ca was restricted to 12.5 mmol/d throughout. During each dietary period, fasting morning first void urine samples (last 3 d) and fasting blood serum samples (morning of twelfth day) were collected. Increasing Na intake from 80 to 180 mmol/d increased urinary Na about twofold in both the Na-sensitive and Na-non-sensitive groups and increased urinary Ca excretion (by 73%) in the Na-sensitive group only. Biochemical markers of bone resorption (urinary pyridinoline and deoxypyridinoline) and bone formation (serum osteocalcin and bone-specific alkaline phosphatase; EC 3.1.3.1) were unaffected by increasing dietary Na in either group. It is concluded that the Na-induced calciuria observed in the Na-sensitive healthy young women did not result in increased bone resorption or turnover and, despite restricted Ca intake, adaptation of dietary Ca absorption may have compensated for the increased urinary Ca loss.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, University College, Cork, Ireland.

    ,

    Source

    The British journal of nutrition 79:4 1998 Apr pg 343-50

    MeSH

    Adult
    Alkaline Phosphatase
    Amino Acids
    Biomarkers
    Bone Remodeling
    Bone and Bones
    Calcium
    Cross-Over Studies
    Female
    Humans
    Osteocalcin
    Sodium
    Sodium, Dietary

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9624225

    Citation

    Ginty, F, et al. "The Effect of Dietary Sodium Intake On Biochemical Markers of Bone Metabolism in Young Women." The British Journal of Nutrition, vol. 79, no. 4, 1998, pp. 343-50.
    Ginty F, Flynn A, Cashman KD. The effect of dietary sodium intake on biochemical markers of bone metabolism in young women. Br J Nutr. 1998;79(4):343-50.
    Ginty, F., Flynn, A., & Cashman, K. D. (1998). The effect of dietary sodium intake on biochemical markers of bone metabolism in young women. The British Journal of Nutrition, 79(4), pp. 343-50.
    Ginty F, Flynn A, Cashman KD. The Effect of Dietary Sodium Intake On Biochemical Markers of Bone Metabolism in Young Women. Br J Nutr. 1998;79(4):343-50. PubMed PMID: 9624225.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of dietary sodium intake on biochemical markers of bone metabolism in young women. AU - Ginty,F, AU - Flynn,A, AU - Cashman,K D, PY - 1998/6/13/pubmed PY - 1998/6/13/medline PY - 1998/6/13/entrez SP - 343 EP - 50 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 79 IS - 4 N2 - To investigate the effect of a low (80 mmol/d) or high (180 mmol/d) Na intake for 14d on biochemical markers of bone turnover in Na-sensitive and Na-non-sensitive healthy young women, twenty-nine subjects were screened for responsiveness of urinary Ca excretion to increasing dietary Na intake (40, 80, 120 and 200 mmol/d for 7 d). In a crossover study, the eight Na-sensitive and eight of the twenty-one Na-non-sensitive subjects were randomly assigned to diets containing either 80 or 180 mmol Na/d for 14d followed by crossover to the alternative diet for a further 14 d. Dietary Ca was restricted to 12.5 mmol/d throughout. During each dietary period, fasting morning first void urine samples (last 3 d) and fasting blood serum samples (morning of twelfth day) were collected. Increasing Na intake from 80 to 180 mmol/d increased urinary Na about twofold in both the Na-sensitive and Na-non-sensitive groups and increased urinary Ca excretion (by 73%) in the Na-sensitive group only. Biochemical markers of bone resorption (urinary pyridinoline and deoxypyridinoline) and bone formation (serum osteocalcin and bone-specific alkaline phosphatase; EC 3.1.3.1) were unaffected by increasing dietary Na in either group. It is concluded that the Na-induced calciuria observed in the Na-sensitive healthy young women did not result in increased bone resorption or turnover and, despite restricted Ca intake, adaptation of dietary Ca absorption may have compensated for the increased urinary Ca loss. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/9624225/The_effect_of_dietary_sodium_intake_on_biochemical_markers_of_bone_metabolism_in_young_women_ L2 - https://www.cambridge.org/core/product/identifier/S0007114598000592/type/journal_article DB - PRIME DP - Unbound Medicine ER -