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Treatment of pain with sustained-release tramadol 100, 150, 200 mg: results of a post-marketing surveillance study.
Int J Clin Pract. 1998 Mar; 52(2):115-21.IJ

Abstract

In a post-marketing-surveillance study the use of a sustained-release tramadol preparation (Tramal long 100, 150, 200 mg) was investigated in 3153 patients. The intention was to comply with the legal obligation to carry out product surveillance and to collect data on prescribing behaviour. We focused our attention on drug safety and efficacy. Tramal long was used mainly for severe and very severe pain. The most frequently reported causes of pain were diseases of the locomotor system (49.9%), tumours (24.3%), traumas and fractures (10.1%), and neurogenic (9.3%). The mean daily dose was 235.7 mg, usually divided into two doses. The analgesic effect was described as very good or good by 82.5% of the patients. Adverse events occurred in 6.5% of the patients, mostly in the form of typical opioid side-effects such as nausea (3.4%), dizziness (1.5%) and vomiting (1.1%). Severe or unknown side-effects were not reported.

Authors+Show Affiliations

Medical Scientific Division, Grünenthal GmbH, Stolberg, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9624795

Citation

Nossol, S, et al. "Treatment of Pain With Sustained-release Tramadol 100, 150, 200 Mg: Results of a Post-marketing Surveillance Study." International Journal of Clinical Practice, vol. 52, no. 2, 1998, pp. 115-21.
Nossol S, Schwarzbold M, Stadler T. Treatment of pain with sustained-release tramadol 100, 150, 200 mg: results of a post-marketing surveillance study. Int J Clin Pract. 1998;52(2):115-21.
Nossol, S., Schwarzbold, M., & Stadler, T. (1998). Treatment of pain with sustained-release tramadol 100, 150, 200 mg: results of a post-marketing surveillance study. International Journal of Clinical Practice, 52(2), 115-21.
Nossol S, Schwarzbold M, Stadler T. Treatment of Pain With Sustained-release Tramadol 100, 150, 200 Mg: Results of a Post-marketing Surveillance Study. Int J Clin Pract. 1998;52(2):115-21. PubMed PMID: 9624795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of pain with sustained-release tramadol 100, 150, 200 mg: results of a post-marketing surveillance study. AU - Nossol,S, AU - Schwarzbold,M, AU - Stadler,T, PY - 1998/6/13/pubmed PY - 1998/6/13/medline PY - 1998/6/13/entrez SP - 115 EP - 21 JF - International journal of clinical practice JO - Int. J. Clin. Pract. VL - 52 IS - 2 N2 - In a post-marketing-surveillance study the use of a sustained-release tramadol preparation (Tramal long 100, 150, 200 mg) was investigated in 3153 patients. The intention was to comply with the legal obligation to carry out product surveillance and to collect data on prescribing behaviour. We focused our attention on drug safety and efficacy. Tramal long was used mainly for severe and very severe pain. The most frequently reported causes of pain were diseases of the locomotor system (49.9%), tumours (24.3%), traumas and fractures (10.1%), and neurogenic (9.3%). The mean daily dose was 235.7 mg, usually divided into two doses. The analgesic effect was described as very good or good by 82.5% of the patients. Adverse events occurred in 6.5% of the patients, mostly in the form of typical opioid side-effects such as nausea (3.4%), dizziness (1.5%) and vomiting (1.1%). Severe or unknown side-effects were not reported. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/9624795/Treatment_of_pain_with_sustained_release_tramadol_100_150_200_mg:_results_of_a_post_marketing_surveillance_study_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -