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Benefit of uncooked cornstarch in the management of children with dumping syndrome fed exclusively by gastrostomy.
Am J Gastroenterol. 1998 May; 93(5):814-8.AJ

Abstract

OBJECTIVES

Children with dumping syndrome fed exclusively by gastrostomy are difficult to manage because liquid diets are given directly into the antrum. The gastric contents are emptied rapidly into the small intestine, with consequent hyperglycemia followed by a delayed hypoglycemia and multiple, often debilitating, symptoms. Uncooked cornstarch is a complex carbohydrate that provides a slow and continuous glucose source and may delay gastric emptying. The objective of this study was to determine the efficacy of uncooked cornstarch in the treatment of these children.

METHODS

The medical records of eight children with dumping syndrome fed exclusively by gastrostomy were reviewed. Dumping syndrome was diagnosed if there was consistent symptomatology, rapid gastric emptying, and abnormal glucose measurements after a glucose tolerance test. Enough uncooked cornstarch to match hepatic glucose production for 4 h was added to control hypoglycemia, and the feeding formula was modified to control hyperglycemia.

RESULTS

All patients had debilitating symptoms. Weight z-score on admission was -2.31 +/- 0.29. Glucose shifts were controlled in all. There was a significant difference between the maximum (221.3 +/- 19.3 mg/dl vs 121.3 +/- 6.9 mg/dl; p < 0.008) and minimum serum glucose (47 +/- 7.8 mg/dl vs 65.6 +/- 4 mg/dl; p < 0.04) before and after uncooked cornstarch. Weight increased from 11.87 +/- 1.4 kg to 15.10 +/- 2.3 kg (p = 0.06). In seven patients, bolus feedings were successfully administered, and symptoms improved or resolved.

CONCLUSIONS

Uncooked cornstarch controlled the glucose shifts, resolved most of the symptoms, allowed bolus feedings, and enhanced weight gain in these children.

Authors+Show Affiliations

Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts 02115, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9625134

Citation

Borovoy, J, et al. "Benefit of Uncooked Cornstarch in the Management of Children With Dumping Syndrome Fed Exclusively By Gastrostomy." The American Journal of Gastroenterology, vol. 93, no. 5, 1998, pp. 814-8.
Borovoy J, Furuta L, Nurko S. Benefit of uncooked cornstarch in the management of children with dumping syndrome fed exclusively by gastrostomy. Am J Gastroenterol. 1998;93(5):814-8.
Borovoy, J., Furuta, L., & Nurko, S. (1998). Benefit of uncooked cornstarch in the management of children with dumping syndrome fed exclusively by gastrostomy. The American Journal of Gastroenterology, 93(5), 814-8.
Borovoy J, Furuta L, Nurko S. Benefit of Uncooked Cornstarch in the Management of Children With Dumping Syndrome Fed Exclusively By Gastrostomy. Am J Gastroenterol. 1998;93(5):814-8. PubMed PMID: 9625134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefit of uncooked cornstarch in the management of children with dumping syndrome fed exclusively by gastrostomy. AU - Borovoy,J, AU - Furuta,L, AU - Nurko,S, PY - 1998/6/13/pubmed PY - 1998/6/13/medline PY - 1998/6/13/entrez SP - 814 EP - 8 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 93 IS - 5 N2 - OBJECTIVES: Children with dumping syndrome fed exclusively by gastrostomy are difficult to manage because liquid diets are given directly into the antrum. The gastric contents are emptied rapidly into the small intestine, with consequent hyperglycemia followed by a delayed hypoglycemia and multiple, often debilitating, symptoms. Uncooked cornstarch is a complex carbohydrate that provides a slow and continuous glucose source and may delay gastric emptying. The objective of this study was to determine the efficacy of uncooked cornstarch in the treatment of these children. METHODS: The medical records of eight children with dumping syndrome fed exclusively by gastrostomy were reviewed. Dumping syndrome was diagnosed if there was consistent symptomatology, rapid gastric emptying, and abnormal glucose measurements after a glucose tolerance test. Enough uncooked cornstarch to match hepatic glucose production for 4 h was added to control hypoglycemia, and the feeding formula was modified to control hyperglycemia. RESULTS: All patients had debilitating symptoms. Weight z-score on admission was -2.31 +/- 0.29. Glucose shifts were controlled in all. There was a significant difference between the maximum (221.3 +/- 19.3 mg/dl vs 121.3 +/- 6.9 mg/dl; p < 0.008) and minimum serum glucose (47 +/- 7.8 mg/dl vs 65.6 +/- 4 mg/dl; p < 0.04) before and after uncooked cornstarch. Weight increased from 11.87 +/- 1.4 kg to 15.10 +/- 2.3 kg (p = 0.06). In seven patients, bolus feedings were successfully administered, and symptoms improved or resolved. CONCLUSIONS: Uncooked cornstarch controlled the glucose shifts, resolved most of the symptoms, allowed bolus feedings, and enhanced weight gain in these children. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9625134/Benefit_of_uncooked_cornstarch_in_the_management_of_children_with_dumping_syndrome_fed_exclusively_by_gastrostomy_ L2 - https://Insights.ovid.com/pubmed?pmid=9625134 DB - PRIME DP - Unbound Medicine ER -