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Effects of the ratio of polyunsaturated and monounsaturated fatty acid to saturated fatty acid on rat plasma and liver lipid concentrations.
Lipids. 1998 May; 33(5):481-7.L

Abstract

The effects of dietary monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid + MUFA/saturated fatty acid (PUFA + MUFA/SFA) ratio on plasma and liver lipid concentrations were studied. In experiment I, when rats were fed with 40% fat (energy%, PUFA/SFA ratio 1.0) and 1% (w/w) cholesterol (C) diets for 21 d, a large amount of MUFA (28.1 energy%, PUFA + MUFA/SFA = 5.7) in the diet was found to increase the plasma total C, triacylglycerol (TAG), and phospholipid (PL) as compared with the low-MUFA diet (7.0 energy%, PUFA + MUFA/SFA = 1.4). The plasma very low density lipoprotein (VLDL)-C, VLDL-TAG, VLDL-PL, and low density lipoprotein (LDL)-C increased significantly in the high-MUFA diet group, but high density lipoprotein (HDL)-C did not change significantly. The high-MUFA diet resulted in greater accumulation of liver C but lesser accumulation of TAG. In experiment II, when dietary SFA was fixed at a certain level (13.2 energy%; PUFA + MUFA/SFA = 2.0), rats given a larger amount of MUFA (23.1 energy%; PUFA/MUFA = 0.2; MUFA/SFA = 1.8) showed higher plasma and liver C levels than did the low-MUFA diet (7.7 energy%; PUFA/MUFA = 2.5; MUFA/SFA = 0.6). When PUFA was fixed at a certain level (24.4 energy%), there was not a significant difference in the plasma C level between the high- and low-MUFA dietary groups (PUFA + MUFA/SFA = 4.8 and 8.4), but the higher PUFA + MUFA/SFA diet, which was high in MUFA/SFA ratio, significantly decreased the plasma HDL-C and TAG levels. However, when MUFA content was fixed at a certain level (16.4 energy%), no significant difference was observed between the two groups with different PUFA/SFA ratios of 0.2 and 4.1, but liver C level was raised in the higher PUFA/SFA diet. It appears that the PUFA/SFA ratio alone is unsuitable to predict the change of plasma C level, because a large amount of dietary MUFA may lead to an increase of plasma and liver lipids in rats. It seems that the prerequisites for keeping low plasma and liver C are (i) low MUFA/SFA ratio, (ii) high PUFA/MUFA ratio, and (iii) PUFA + MUFA/SFA ratio not to exceed 2.

Authors+Show Affiliations

Department of Biochemistry, China Medical College, Taichung, Taiwan, Republic of China. nwchang@mail.cmc.edu.twNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9625595

Citation

Chang, N W., and P C. Huang. "Effects of the Ratio of Polyunsaturated and Monounsaturated Fatty Acid to Saturated Fatty Acid On Rat Plasma and Liver Lipid Concentrations." Lipids, vol. 33, no. 5, 1998, pp. 481-7.
Chang NW, Huang PC. Effects of the ratio of polyunsaturated and monounsaturated fatty acid to saturated fatty acid on rat plasma and liver lipid concentrations. Lipids. 1998;33(5):481-7.
Chang, N. W., & Huang, P. C. (1998). Effects of the ratio of polyunsaturated and monounsaturated fatty acid to saturated fatty acid on rat plasma and liver lipid concentrations. Lipids, 33(5), 481-7.
Chang NW, Huang PC. Effects of the Ratio of Polyunsaturated and Monounsaturated Fatty Acid to Saturated Fatty Acid On Rat Plasma and Liver Lipid Concentrations. Lipids. 1998;33(5):481-7. PubMed PMID: 9625595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the ratio of polyunsaturated and monounsaturated fatty acid to saturated fatty acid on rat plasma and liver lipid concentrations. AU - Chang,N W, AU - Huang,P C, PY - 1998/6/13/pubmed PY - 1998/6/13/medline PY - 1998/6/13/entrez SP - 481 EP - 7 JF - Lipids JO - Lipids VL - 33 IS - 5 N2 - The effects of dietary monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid + MUFA/saturated fatty acid (PUFA + MUFA/SFA) ratio on plasma and liver lipid concentrations were studied. In experiment I, when rats were fed with 40% fat (energy%, PUFA/SFA ratio 1.0) and 1% (w/w) cholesterol (C) diets for 21 d, a large amount of MUFA (28.1 energy%, PUFA + MUFA/SFA = 5.7) in the diet was found to increase the plasma total C, triacylglycerol (TAG), and phospholipid (PL) as compared with the low-MUFA diet (7.0 energy%, PUFA + MUFA/SFA = 1.4). The plasma very low density lipoprotein (VLDL)-C, VLDL-TAG, VLDL-PL, and low density lipoprotein (LDL)-C increased significantly in the high-MUFA diet group, but high density lipoprotein (HDL)-C did not change significantly. The high-MUFA diet resulted in greater accumulation of liver C but lesser accumulation of TAG. In experiment II, when dietary SFA was fixed at a certain level (13.2 energy%; PUFA + MUFA/SFA = 2.0), rats given a larger amount of MUFA (23.1 energy%; PUFA/MUFA = 0.2; MUFA/SFA = 1.8) showed higher plasma and liver C levels than did the low-MUFA diet (7.7 energy%; PUFA/MUFA = 2.5; MUFA/SFA = 0.6). When PUFA was fixed at a certain level (24.4 energy%), there was not a significant difference in the plasma C level between the high- and low-MUFA dietary groups (PUFA + MUFA/SFA = 4.8 and 8.4), but the higher PUFA + MUFA/SFA diet, which was high in MUFA/SFA ratio, significantly decreased the plasma HDL-C and TAG levels. However, when MUFA content was fixed at a certain level (16.4 energy%), no significant difference was observed between the two groups with different PUFA/SFA ratios of 0.2 and 4.1, but liver C level was raised in the higher PUFA/SFA diet. It appears that the PUFA/SFA ratio alone is unsuitable to predict the change of plasma C level, because a large amount of dietary MUFA may lead to an increase of plasma and liver lipids in rats. It seems that the prerequisites for keeping low plasma and liver C are (i) low MUFA/SFA ratio, (ii) high PUFA/MUFA ratio, and (iii) PUFA + MUFA/SFA ratio not to exceed 2. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/9625595/Effects_of_the_ratio_of_polyunsaturated_and_monounsaturated_fatty_acid_to_saturated_fatty_acid_on_rat_plasma_and_liver_lipid_concentrations_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1998&volume=33&issue=5&spage=481 DB - PRIME DP - Unbound Medicine ER -