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Apomorphine does not influence olfactory thresholds in Parkinson's disease.
Funct Neurol. 1998 Apr-Jun; 13(2):99-103.FN

Abstract

In order to verify the presumed dopaminergic basis of olfactory dysfunction in Parkinson's disease (PD), we studied olfactory functions in 12 PD patients (mean age 60.1 yrs, mean duration of PD 9.0 yrs, mean Hoehn and Yahr score 2.8) before and after apomorphine (APO) administration. Amylacetate (banana smell) in 12 sequential dilutions (in 50% steps) was used for the examination of olfactory thresholds. The testing showed no significant differences in any olfactory parameters before and after APO. Furthermore, when analysing the subgroup of 7 hyposmic PD patients, we also found no significant differences before and after APO. We therefore believe that olfactory dysfunction in PD is not dependent on dopamine deficiency.

Authors+Show Affiliations

Clinic of Neurology, Charles University, Prague, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9626594

Citation

Roth, J, et al. "Apomorphine Does Not Influence Olfactory Thresholds in Parkinson's Disease." Functional Neurology, vol. 13, no. 2, 1998, pp. 99-103.
Roth J, Radil T, Růzicka E, et al. Apomorphine does not influence olfactory thresholds in Parkinson's disease. Funct Neurol. 1998;13(2):99-103.
Roth, J., Radil, T., Růzicka, E., Jech, R., & Tichý, J. (1998). Apomorphine does not influence olfactory thresholds in Parkinson's disease. Functional Neurology, 13(2), 99-103.
Roth J, et al. Apomorphine Does Not Influence Olfactory Thresholds in Parkinson's Disease. Funct Neurol. 1998 Apr-Jun;13(2):99-103. PubMed PMID: 9626594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apomorphine does not influence olfactory thresholds in Parkinson's disease. AU - Roth,J, AU - Radil,T, AU - Růzicka,E, AU - Jech,R, AU - Tichý,J, PY - 1998/6/17/pubmed PY - 1998/6/17/medline PY - 1998/6/17/entrez SP - 99 EP - 103 JF - Functional neurology JO - Funct. Neurol. VL - 13 IS - 2 N2 - In order to verify the presumed dopaminergic basis of olfactory dysfunction in Parkinson's disease (PD), we studied olfactory functions in 12 PD patients (mean age 60.1 yrs, mean duration of PD 9.0 yrs, mean Hoehn and Yahr score 2.8) before and after apomorphine (APO) administration. Amylacetate (banana smell) in 12 sequential dilutions (in 50% steps) was used for the examination of olfactory thresholds. The testing showed no significant differences in any olfactory parameters before and after APO. Furthermore, when analysing the subgroup of 7 hyposmic PD patients, we also found no significant differences before and after APO. We therefore believe that olfactory dysfunction in PD is not dependent on dopamine deficiency. SN - 0393-5264 UR - https://www.unboundmedicine.com/medline/citation/9626594/Apomorphine_does_not_influence_olfactory_thresholds_in_Parkinson's_disease_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -