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Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women.
J Bone Miner Res 1998; 13(6):1045-50JB

Abstract

Bone mobilization, lowering of bone mineral density (BMD), and osteoporotic fractures are recognized in postmenopausal women with weight loss. Because a high-calcium intake suppresses bone loss in peri- and postmenopausal women, the present randomized, double-blind, placebo-controlled study was designed to test the hypothesis that calcium supplementation prevents net bone mobilization and consequent bone mineral loss during voluntary weight reduction in obese postmenopausal women. Subjects were placed on a moderate energy-restricted diet and either calcium supplementation (1 g/day) or placebo for 6 months. Body weight, bone turnover markers (pyridinium cross-links), osteocalcin, and parathyroid hormone (PTH) were measured at treatment weeks 1-5, 7, 10, 13, 16, 20, and 25. Total body BMD, insulin-like growth factor, 25-hydroxyvitamin D, and sex hormone binding globulin (SHBG) were measured at baseline and week 25. The calcium supplemented (n = 15; age 60.9 +/- 9.4 years, body mass index [BMI] 33.2 +/- 4.6 kg/m2) and placebo (n = 16; age 55.8 +/- 8.3 years, BMI 32.9 +/- 4.5 kg/m2) groups lost similar amounts of weight over the study interval (10.2 +/- 5.3% vs. 10.0 +/- 5.2%) and both groups increased SHBG (p < 0.001). There was a statistical effect of calcium supplementation during weight loss to suppress pyridinium cross-links, osteocalcin, and PTH (p < 0.05, < 0.01, and < 0.05, respectively). Loss of BMD tended to be greater in the placebo group by 1.4% (p < 0.08) after weight loss. One gram per day calcium supplementation normalizes the increased calcium-PTH axis activity and the elevated bone turnover rate observed during moderate voluntary energy restriction in postmenopausal women.

Authors+Show Affiliations

Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9626637

Citation

Ricci, T A., et al. "Calcium Supplementation Suppresses Bone Turnover During Weight Reduction in Postmenopausal Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 13, no. 6, 1998, pp. 1045-50.
Ricci TA, Chowdhury HA, Heymsfield SB, et al. Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women. J Bone Miner Res. 1998;13(6):1045-50.
Ricci, T. A., Chowdhury, H. A., Heymsfield, S. B., Stahl, T., Pierson, R. N., & Shapses, S. A. (1998). Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 13(6), pp. 1045-50.
Ricci TA, et al. Calcium Supplementation Suppresses Bone Turnover During Weight Reduction in Postmenopausal Women. J Bone Miner Res. 1998;13(6):1045-50. PubMed PMID: 9626637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women. AU - Ricci,T A, AU - Chowdhury,H A, AU - Heymsfield,S B, AU - Stahl,T, AU - Pierson,R N,Jr AU - Shapses,S A, PY - 1998/6/17/pubmed PY - 2001/3/28/medline PY - 1998/6/17/entrez SP - 1045 EP - 50 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 13 IS - 6 N2 - Bone mobilization, lowering of bone mineral density (BMD), and osteoporotic fractures are recognized in postmenopausal women with weight loss. Because a high-calcium intake suppresses bone loss in peri- and postmenopausal women, the present randomized, double-blind, placebo-controlled study was designed to test the hypothesis that calcium supplementation prevents net bone mobilization and consequent bone mineral loss during voluntary weight reduction in obese postmenopausal women. Subjects were placed on a moderate energy-restricted diet and either calcium supplementation (1 g/day) or placebo for 6 months. Body weight, bone turnover markers (pyridinium cross-links), osteocalcin, and parathyroid hormone (PTH) were measured at treatment weeks 1-5, 7, 10, 13, 16, 20, and 25. Total body BMD, insulin-like growth factor, 25-hydroxyvitamin D, and sex hormone binding globulin (SHBG) were measured at baseline and week 25. The calcium supplemented (n = 15; age 60.9 +/- 9.4 years, body mass index [BMI] 33.2 +/- 4.6 kg/m2) and placebo (n = 16; age 55.8 +/- 8.3 years, BMI 32.9 +/- 4.5 kg/m2) groups lost similar amounts of weight over the study interval (10.2 +/- 5.3% vs. 10.0 +/- 5.2%) and both groups increased SHBG (p < 0.001). There was a statistical effect of calcium supplementation during weight loss to suppress pyridinium cross-links, osteocalcin, and PTH (p < 0.05, < 0.01, and < 0.05, respectively). Loss of BMD tended to be greater in the placebo group by 1.4% (p < 0.08) after weight loss. One gram per day calcium supplementation normalizes the increased calcium-PTH axis activity and the elevated bone turnover rate observed during moderate voluntary energy restriction in postmenopausal women. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/9626637/Calcium_supplementation_suppresses_bone_turnover_during_weight_reduction_in_postmenopausal_women_ L2 - https://doi.org/10.1359/jbmr.1998.13.6.1045 DB - PRIME DP - Unbound Medicine ER -