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Effects of supplementation with a combination of antioxidant vitamins and trace elements, at nutritional doses, on biochemical indicators and markers of the antioxidant system in adult subjects.
J Am Coll Nutr 1998; 17(3):244-9JA

Abstract

OBJECTIVE

To test the impact of supplementation with nutritional doses of antioxidant nutrients on biochemical indicators of vitamin and trace element levels.

DESIGN

A randomized double-blind trial was performed comparing two groups receiving daily either a combination of vitamins (beta-carotene, 6 mg; vitamin C, 120 mg; and vitamin E, 30 mg) and trace elements (zinc, 20 mg; and selenium, 100 micrograms); or a placebo.

SUBJECTS

401 subjects (166 males aged 45 to 60 years and 235 females aged to 35 to 60 years). MEASURE OF OUTCOME: Biological markers of vitamin and trace element status and free radical parameters were measured initially, 3 months, and 6 months after supplemention.

RESULTS

Mean serum concentrations of alpha-tocopherol, vitamin C, beta-carotene, zinc and selenium increased significantly after 3 months of supplementation in the group receiving multivitamins associated with minerals. At baseline, 18.2% of the men and 5.1% of the women had low concentrations of serum vitamin C (< 20 mumol/l): 2.4% of the men and 17% of the women presented low concentrations of serum retinol (< 1.4 mumol/l): 18.7% of men and 10% of women had serum beta-carotene < 0.30 mumol/l. None of the study subjects had serum alpha-tocopherol concentrations below the limit cut-off point (< 9.3 mumol/l). Low serum zinc concentrations (< 10.7 mumol/l) were found in 15.1% of men and 23.8% of women. Low serum selenium concentrations (< 0.75 mumol/l) were found in 6% of men and 6.4% of women. A significant increase in plasma and red cell GPx activity was observed in groups receiving supplementation. No modifications were observed after 6 months of supplementation for malondyaldehyde.

CONCLUSION

This study demonstrates the efficacy of an intake of antioxidant vitamins and trace elements, given at nutritional doses, on biochemical indicators of vitamin and trace elements status.

Authors+Show Affiliations

Institut Scientifique et Technique de la Nutrition et l'Alimentation, Conservatoire National des Arts et Métiers, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9627910

Citation

Preziosi, P, et al. "Effects of Supplementation With a Combination of Antioxidant Vitamins and Trace Elements, at Nutritional Doses, On Biochemical Indicators and Markers of the Antioxidant System in Adult Subjects." Journal of the American College of Nutrition, vol. 17, no. 3, 1998, pp. 244-9.
Preziosi P, Galan P, Herbeth B, et al. Effects of supplementation with a combination of antioxidant vitamins and trace elements, at nutritional doses, on biochemical indicators and markers of the antioxidant system in adult subjects. J Am Coll Nutr. 1998;17(3):244-9.
Preziosi, P., Galan, P., Herbeth, B., Valeix, P., Roussel, A. M., Malvy, D., ... Hercberg, S. (1998). Effects of supplementation with a combination of antioxidant vitamins and trace elements, at nutritional doses, on biochemical indicators and markers of the antioxidant system in adult subjects. Journal of the American College of Nutrition, 17(3), pp. 244-9.
Preziosi P, et al. Effects of Supplementation With a Combination of Antioxidant Vitamins and Trace Elements, at Nutritional Doses, On Biochemical Indicators and Markers of the Antioxidant System in Adult Subjects. J Am Coll Nutr. 1998;17(3):244-9. PubMed PMID: 9627910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplementation with a combination of antioxidant vitamins and trace elements, at nutritional doses, on biochemical indicators and markers of the antioxidant system in adult subjects. AU - Preziosi,P, AU - Galan,P, AU - Herbeth,B, AU - Valeix,P, AU - Roussel,A M, AU - Malvy,D, AU - Paul-Dauphin,A, AU - Arnaud,J, AU - Richard,M J, AU - Briancon,S, AU - Favier,A, AU - Hercberg,S, PY - 1998/6/17/pubmed PY - 1998/6/17/medline PY - 1998/6/17/entrez SP - 244 EP - 9 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 17 IS - 3 N2 - OBJECTIVE: To test the impact of supplementation with nutritional doses of antioxidant nutrients on biochemical indicators of vitamin and trace element levels. DESIGN: A randomized double-blind trial was performed comparing two groups receiving daily either a combination of vitamins (beta-carotene, 6 mg; vitamin C, 120 mg; and vitamin E, 30 mg) and trace elements (zinc, 20 mg; and selenium, 100 micrograms); or a placebo. SUBJECTS: 401 subjects (166 males aged 45 to 60 years and 235 females aged to 35 to 60 years). MEASURE OF OUTCOME: Biological markers of vitamin and trace element status and free radical parameters were measured initially, 3 months, and 6 months after supplemention. RESULTS: Mean serum concentrations of alpha-tocopherol, vitamin C, beta-carotene, zinc and selenium increased significantly after 3 months of supplementation in the group receiving multivitamins associated with minerals. At baseline, 18.2% of the men and 5.1% of the women had low concentrations of serum vitamin C (< 20 mumol/l): 2.4% of the men and 17% of the women presented low concentrations of serum retinol (< 1.4 mumol/l): 18.7% of men and 10% of women had serum beta-carotene < 0.30 mumol/l. None of the study subjects had serum alpha-tocopherol concentrations below the limit cut-off point (< 9.3 mumol/l). Low serum zinc concentrations (< 10.7 mumol/l) were found in 15.1% of men and 23.8% of women. Low serum selenium concentrations (< 0.75 mumol/l) were found in 6% of men and 6.4% of women. A significant increase in plasma and red cell GPx activity was observed in groups receiving supplementation. No modifications were observed after 6 months of supplementation for malondyaldehyde. CONCLUSION: This study demonstrates the efficacy of an intake of antioxidant vitamins and trace elements, given at nutritional doses, on biochemical indicators of vitamin and trace elements status. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/9627910/Effects_of_supplementation_with_a_combination_of_antioxidant_vitamins_and_trace_elements_at_nutritional_doses_on_biochemical_indicators_and_markers_of_the_antioxidant_system_in_adult_subjects_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.1998.10718754 DB - PRIME DP - Unbound Medicine ER -