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Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity.
Altern Med Rev. 1998 Jun; 3(3):199-207.AM

Abstract

Heavy metals are, unfortunately, present in the air, water, and food supply. Cases of severe acute lead, mercury, arsenic, and cadmium poisoning are rare; however, when they do occur an effective, non-toxic treatment is essential. In addition, chronic, low-level exposure to lead in the soil and in residues of lead-based paint, to mercury in the atmosphere, in dental amalgams and in seafood, and to cadmium and arsenic in the environment and in cigarette smoke is much more common than acute exposure. Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound s efficacy and safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion, and its safety characteristics compared to other chelating substances.

Authors+Show Affiliations

Alternative Medicine Review. P.O. Box 25, Dover, ID 83825, USA. alan@thorne.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9630737

Citation

Miller, A L.. "Dimercaptosuccinic Acid (DMSA), a Non-toxic, Water-soluble Treatment for Heavy Metal Toxicity." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 3, no. 3, 1998, pp. 199-207.
Miller AL. Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Altern Med Rev. 1998;3(3):199-207.
Miller, A. L. (1998). Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Alternative Medicine Review : a Journal of Clinical Therapeutic, 3(3), 199-207.
Miller AL. Dimercaptosuccinic Acid (DMSA), a Non-toxic, Water-soluble Treatment for Heavy Metal Toxicity. Altern Med Rev. 1998;3(3):199-207. PubMed PMID: 9630737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. A1 - Miller,A L, PY - 1998/6/19/pubmed PY - 1998/6/19/medline PY - 1998/6/19/entrez SP - 199 EP - 207 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 3 IS - 3 N2 - Heavy metals are, unfortunately, present in the air, water, and food supply. Cases of severe acute lead, mercury, arsenic, and cadmium poisoning are rare; however, when they do occur an effective, non-toxic treatment is essential. In addition, chronic, low-level exposure to lead in the soil and in residues of lead-based paint, to mercury in the atmosphere, in dental amalgams and in seafood, and to cadmium and arsenic in the environment and in cigarette smoke is much more common than acute exposure. Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound s efficacy and safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion, and its safety characteristics compared to other chelating substances. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/9630737/Dimercaptosuccinic_acid__DMSA__a_non_toxic_water_soluble_treatment_for_heavy_metal_toxicity_ L2 - http://archive.foundationalmedicinereview.com/publications/3/3/199.pdf DB - PRIME DP - Unbound Medicine ER -