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Effects of meal ingestion and active standing on blood pressure in patients > or = 60 years of age.
Am J Cardiol. 1998 Jun 01; 81(11):1310-4.AJ

Abstract

Postprandial hypotension and orthostatic hypotension occur often in elderly patients. In the present study, we examined hemodynamic and humoral responses to meal ingestion and active standing in 20 patients > or = 60 years of age who were free of apparent autonomic and cardiac dysfunction. For a time-control study, water was given instead of a meal to 19 of the 20 patients. After the meal ingestion, there was a fall in systolic blood pressure (BP) in 6 patients of > 20 mm Hg, whereas the fall in systolic BP during the control study was not > 20 mm Hg in any patient. The low-frequency power of the systolic BP wave, an index of peripheral sympathetic activity, was significantly increased only in the patients without postprandial hypotension. The postprandial changes in systolic BP were correlated with the changes in the low-frequency power of the systolic BP wave (r = 0.61; p < 0.01), but they were not correlated with the changes in plasma norepinephrine, insulin, cardiac output, or parameters obtained by the spectral analysis of the RR interval. The systolic BPs in the upright position were comparable after the meal and the water ingestion. Thus, the effects of meal ingestion and upright position on BP are not additive. Dysfunction of peripheral sympathetic control of vascular tone may contribute to the postprandial hypotension in elderly patients.

Authors+Show Affiliations

Third Department of Internal Medicine, University of the Ryukyus School of Medicine, Okinawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9631968

Citation

Imai, C, et al. "Effects of Meal Ingestion and Active Standing On Blood Pressure in Patients > or = 60 Years of Age." The American Journal of Cardiology, vol. 81, no. 11, 1998, pp. 1310-4.
Imai C, Muratani H, Kimura Y, et al. Effects of meal ingestion and active standing on blood pressure in patients > or = 60 years of age. Am J Cardiol. 1998;81(11):1310-4.
Imai, C., Muratani, H., Kimura, Y., Kanzato, N., Takishita, S., & Fukiyama, K. (1998). Effects of meal ingestion and active standing on blood pressure in patients > or = 60 years of age. The American Journal of Cardiology, 81(11), 1310-4.
Imai C, et al. Effects of Meal Ingestion and Active Standing On Blood Pressure in Patients > or = 60 Years of Age. Am J Cardiol. 1998 Jun 1;81(11):1310-4. PubMed PMID: 9631968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of meal ingestion and active standing on blood pressure in patients > or = 60 years of age. AU - Imai,C, AU - Muratani,H, AU - Kimura,Y, AU - Kanzato,N, AU - Takishita,S, AU - Fukiyama,K, PY - 1998/6/19/pubmed PY - 1998/6/19/medline PY - 1998/6/19/entrez SP - 1310 EP - 4 JF - The American journal of cardiology JO - Am J Cardiol VL - 81 IS - 11 N2 - Postprandial hypotension and orthostatic hypotension occur often in elderly patients. In the present study, we examined hemodynamic and humoral responses to meal ingestion and active standing in 20 patients > or = 60 years of age who were free of apparent autonomic and cardiac dysfunction. For a time-control study, water was given instead of a meal to 19 of the 20 patients. After the meal ingestion, there was a fall in systolic blood pressure (BP) in 6 patients of > 20 mm Hg, whereas the fall in systolic BP during the control study was not > 20 mm Hg in any patient. The low-frequency power of the systolic BP wave, an index of peripheral sympathetic activity, was significantly increased only in the patients without postprandial hypotension. The postprandial changes in systolic BP were correlated with the changes in the low-frequency power of the systolic BP wave (r = 0.61; p < 0.01), but they were not correlated with the changes in plasma norepinephrine, insulin, cardiac output, or parameters obtained by the spectral analysis of the RR interval. The systolic BPs in the upright position were comparable after the meal and the water ingestion. Thus, the effects of meal ingestion and upright position on BP are not additive. Dysfunction of peripheral sympathetic control of vascular tone may contribute to the postprandial hypotension in elderly patients. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/9631968/Effects_of_meal_ingestion_and_active_standing_on_blood_pressure_in_patients_>_or_=_60_years_of_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002914998001635 DB - PRIME DP - Unbound Medicine ER -