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Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia.
J Am Acad Dermatol. 1998 Jun; 38(6 Pt 1):967-70.JA

Abstract

BACKGROUND

Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present.

OBJECTIVE

The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia.

METHODS

Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide.

RESULTS

Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found.

CONCLUSION

Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia.

Authors+Show Affiliations

Mayo Clinic Scottsdale, Ariz, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9632006

Citation

Winkelmann, R K., et al. "Asteroid Bodies and Other Cytoplasmic Inclusions in Necrobiotic Xanthogranuloma With Paraproteinemia." Journal of the American Academy of Dermatology, vol. 38, no. 6 Pt 1, 1998, pp. 967-70.
Winkelmann RK, Dahl PR, Perniciaro C, et al. Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia. J Am Acad Dermatol. 1998;38(6 Pt 1):967-70.
Winkelmann, R. K., Dahl, P. R., Perniciaro, C., & Dahl, P. M. (1998). Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia. Journal of the American Academy of Dermatology, 38(6 Pt 1), 967-70.
Winkelmann RK, et al. Asteroid Bodies and Other Cytoplasmic Inclusions in Necrobiotic Xanthogranuloma With Paraproteinemia. J Am Acad Dermatol. 1998;38(6 Pt 1):967-70. PubMed PMID: 9632006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia. AU - Winkelmann,R K, AU - Dahl,P R, AU - Perniciaro,C, AU - Dahl,P M, PY - 1998/6/19/pubmed PY - 1998/6/19/medline PY - 1998/6/19/entrez SP - 967 EP - 70 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 38 IS - 6 Pt 1 N2 - BACKGROUND: Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present. OBJECTIVE: The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia. METHODS: Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide. RESULTS: Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found. CONCLUSION: Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/9632006/Asteroid_bodies_and_other_cytoplasmic_inclusions_in_necrobiotic_xanthogranuloma_with_paraproteinemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(98)70161-6 DB - PRIME DP - Unbound Medicine ER -