Tags

Type your tag names separated by a space and hit enter

Treating antidepressant nonresponders with augmentation strategies: an overview.
J Clin Psychiatry 1998; 59 Suppl 5:5-12; discussion 13-5JC

Abstract

This paper provides an overview of antidepressant nonresponse and the role of augmentation strategies in the management of treatment-resistant depression. When effective, the more widely used augmentation strategies, including lithium salts, thyroid hormones, pindolol, buspirone, and psychostimulants, share two important advantages when compared with "switching" strategies: avoidance of ill effects associated with discontinuing the initial antidepressant and rapidity of onset of action. Ideally, advances in the understanding of the neurobiology of mood disorders and mechanisms of antidepressant response will permit a more efficient and specific matching between patient, initial antidepressant, and subsequent strategy for enhancing response to treatment.

Authors+Show Affiliations

Department of Psychiatry, University of Pittsburgh School of Medicine, and the Western Psychiatric Institute and Clinic, PA 15213, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9635543

Citation

Thase, M E., et al. "Treating Antidepressant Nonresponders With Augmentation Strategies: an Overview." The Journal of Clinical Psychiatry, vol. 59 Suppl 5, 1998, pp. 5-12; discussion 13-5.
Thase ME, Howland RH, Friedman ES. Treating antidepressant nonresponders with augmentation strategies: an overview. J Clin Psychiatry. 1998;59 Suppl 5:5-12; discussion 13-5.
Thase, M. E., Howland, R. H., & Friedman, E. S. (1998). Treating antidepressant nonresponders with augmentation strategies: an overview. The Journal of Clinical Psychiatry, 59 Suppl 5, pp. 5-12; discussion 13-5.
Thase ME, Howland RH, Friedman ES. Treating Antidepressant Nonresponders With Augmentation Strategies: an Overview. J Clin Psychiatry. 1998;59 Suppl 5:5-12; discussion 13-5. PubMed PMID: 9635543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treating antidepressant nonresponders with augmentation strategies: an overview. AU - Thase,M E, AU - Howland,R H, AU - Friedman,E S, PY - 1998/6/27/pubmed PY - 1998/6/27/medline PY - 1998/6/27/entrez SP - 5-12; discussion 13-5 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 59 Suppl 5 N2 - This paper provides an overview of antidepressant nonresponse and the role of augmentation strategies in the management of treatment-resistant depression. When effective, the more widely used augmentation strategies, including lithium salts, thyroid hormones, pindolol, buspirone, and psychostimulants, share two important advantages when compared with "switching" strategies: avoidance of ill effects associated with discontinuing the initial antidepressant and rapidity of onset of action. Ideally, advances in the understanding of the neurobiology of mood disorders and mechanisms of antidepressant response will permit a more efficient and specific matching between patient, initial antidepressant, and subsequent strategy for enhancing response to treatment. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/9635543/Treating_antidepressant_nonresponders_with_augmentation_strategies:_an_overview_ L2 - http://www.psychiatrist.com/jcp/article/pages/1998/v59s05/v59s0502.aspx DB - PRIME DP - Unbound Medicine ER -