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[Zinc protoporphyrin (ZPP) in diagnosis of anemia].
Pol Arch Med Wewn. 1997 Dec; 98(12):520-6.PA

Abstract

In iron deficiency, zinc protoporphyrin (ZPP) is produced instead of heme, and the ZPP concentration in erythrocytes increased (normal value < 2.3 micrograms ZPP/g Hb). The ZPP level and comparison with the other normally used tests in iron deficiency in the group of the patients with iron deficiency, ACD, MDS, AML, plasmocytoma was investigated. The ZPP level was determined by hematofluorometry in samples from 96 patients. Thirty five patients with iron depletion showed decreased both serum ferritin (median 5.9 ng/ml), and hemoglobin level (median 9.8 g/dl) with significantly increased ZPP level (median 8.5 micrograms/gHb). An increased level of ZPP (median 3.95 micrograms/gHb) with normal level of ferritin (median 24 ng/ml) and iron (median 50 (g/dl) in the serum of patients with ACD was determined. Measurement of ZPP level in the combination with ferritin and peripheral blood morphology allows to classify the degree of iron deficiency. The ZPP levels higher than 4.55 micrograms/gHb confirms iron deficiency in the group of anaemic patients.

Authors+Show Affiliations

Paszkowska M
Klinika Hematologii Akademii Medycznej, Warszawie.
Jezyńska A
No affiliation info available
Król M
No affiliation info available
Rokicka-Piotrowicz M
No affiliation info available
Kuratowska Z
No affiliation info available

MeSH

AnemiaErythrocytesFerritinsHeme Oxygenase (Decyclizing)HemoglobinsHumansProtoporphyrinsReference Values

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

pol

PubMed ID

9640080

Citation

Paszkowska, M, et al. "[Zinc Protoporphyrin (ZPP) in Diagnosis of Anemia]." Polskie Archiwum Medycyny Wewnetrznej, vol. 98, no. 12, 1997, pp. 520-6.
Paszkowska M, Jezyńska A, Król M, et al. [Zinc protoporphyrin (ZPP) in diagnosis of anemia]. Pol Arch Med Wewn. 1997;98(12):520-6.
Paszkowska, M., Jezyńska, A., Król, M., Rokicka-Piotrowicz, M., & Kuratowska, Z. (1997). [Zinc protoporphyrin (ZPP) in diagnosis of anemia]. Polskie Archiwum Medycyny Wewnetrznej, 98(12), 520-6.
Paszkowska M, et al. [Zinc Protoporphyrin (ZPP) in Diagnosis of Anemia]. Pol Arch Med Wewn. 1997;98(12):520-6. PubMed PMID: 9640080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Zinc protoporphyrin (ZPP) in diagnosis of anemia]. AU - Paszkowska,M, AU - Jezyńska,A, AU - Król,M, AU - Rokicka-Piotrowicz,M, AU - Kuratowska,Z, PY - 1998/6/26/pubmed PY - 1998/6/26/medline PY - 1998/6/26/entrez SP - 520 EP - 6 JF - Polskie Archiwum Medycyny Wewnetrznej JO - Pol Arch Med Wewn VL - 98 IS - 12 N2 - In iron deficiency, zinc protoporphyrin (ZPP) is produced instead of heme, and the ZPP concentration in erythrocytes increased (normal value < 2.3 micrograms ZPP/g Hb). The ZPP level and comparison with the other normally used tests in iron deficiency in the group of the patients with iron deficiency, ACD, MDS, AML, plasmocytoma was investigated. The ZPP level was determined by hematofluorometry in samples from 96 patients. Thirty five patients with iron depletion showed decreased both serum ferritin (median 5.9 ng/ml), and hemoglobin level (median 9.8 g/dl) with significantly increased ZPP level (median 8.5 micrograms/gHb). An increased level of ZPP (median 3.95 micrograms/gHb) with normal level of ferritin (median 24 ng/ml) and iron (median 50 (g/dl) in the serum of patients with ACD was determined. Measurement of ZPP level in the combination with ferritin and peripheral blood morphology allows to classify the degree of iron deficiency. The ZPP levels higher than 4.55 micrograms/gHb confirms iron deficiency in the group of anaemic patients. UR - https://www.unboundmedicine.com/medline/citation/9640080/[Zinc_protoporphyrin__ZPP__in_diagnosis_of_anemia]_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -