Tags

Type your tag names separated by a space and hit enter

Upper gastrointestinal mucosal lesions in dyspeptic patients with homozygous sickle cell disease in Kenya.
East Afr Med J. 1998 Mar; 75(3):148-50.EA

Abstract

A case controlled study comprising 51 patients with homozygous sickle cell (HbSS) disease who complained of dyspepsia and 41 age and sex matched non-HbSS control dyspeptic patients was carried out, to look at upper gastrointestinal mucosal lesions associated with dyspepsia. Upper gastrointestinal tract (UGIT) endoscopy was performed with gastric control biopsy taken for histology. Thirty two (62.3%) of the HbSS or sickle cell anaemia (SCA) patients had upper gastrointestinal pathology at endoscopy as compared to 17 (41.5%) of controls. The difference was significant at p = 0.042. Bile reflux (47%) was the predominant abnormal morphological finding in SCA patients while duodenal ulcer was the most common morphological finding in dyspeptic controls. The prevalence of duodenal ulcer in controls (22%) though higher than in SCA patients (9.8%), was not statistically significant p = 0.18. Gastric ulcer was not found in SCA patients. Duodenal ulcer was commoner in males than females in both cases and controls with a ratio of 4:1 and 3.5:1 respectively. Only four (7.8%) SCA patients and one (2.4%) of controls had normal mucosa at histology, the rest had evidence of histological gastritis. We could not draw any correlation between non-steroidal anti-inflammatory drugs (NSAIDS) use and UGIT findings. Since the proportion of SCA cases with UGIT abnormalities was significantly high, we recommend that dyspeptic SCA patients undergo UGIT investigations including endoscopy to maximise their clinical care.

Authors+Show Affiliations

Mbagathi District Hospital, Nairobi.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9640811

Citation

Maende, J A., et al. "Upper Gastrointestinal Mucosal Lesions in Dyspeptic Patients With Homozygous Sickle Cell Disease in Kenya." East African Medical Journal, vol. 75, no. 3, 1998, pp. 148-50.
Maende JA, Ogutu EO, Nyong'o A, et al. Upper gastrointestinal mucosal lesions in dyspeptic patients with homozygous sickle cell disease in Kenya. East Afr Med J. 1998;75(3):148-50.
Maende, J. A., Ogutu, E. O., Nyong'o, A., & Aluoch, J. R. (1998). Upper gastrointestinal mucosal lesions in dyspeptic patients with homozygous sickle cell disease in Kenya. East African Medical Journal, 75(3), 148-50.
Maende JA, et al. Upper Gastrointestinal Mucosal Lesions in Dyspeptic Patients With Homozygous Sickle Cell Disease in Kenya. East Afr Med J. 1998;75(3):148-50. PubMed PMID: 9640811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upper gastrointestinal mucosal lesions in dyspeptic patients with homozygous sickle cell disease in Kenya. AU - Maende,J A, AU - Ogutu,E O, AU - Nyong'o,A, AU - Aluoch,J R, PY - 1998/6/26/pubmed PY - 1998/6/26/medline PY - 1998/6/26/entrez SP - 148 EP - 50 JF - East African medical journal JO - East Afr Med J VL - 75 IS - 3 N2 - A case controlled study comprising 51 patients with homozygous sickle cell (HbSS) disease who complained of dyspepsia and 41 age and sex matched non-HbSS control dyspeptic patients was carried out, to look at upper gastrointestinal mucosal lesions associated with dyspepsia. Upper gastrointestinal tract (UGIT) endoscopy was performed with gastric control biopsy taken for histology. Thirty two (62.3%) of the HbSS or sickle cell anaemia (SCA) patients had upper gastrointestinal pathology at endoscopy as compared to 17 (41.5%) of controls. The difference was significant at p = 0.042. Bile reflux (47%) was the predominant abnormal morphological finding in SCA patients while duodenal ulcer was the most common morphological finding in dyspeptic controls. The prevalence of duodenal ulcer in controls (22%) though higher than in SCA patients (9.8%), was not statistically significant p = 0.18. Gastric ulcer was not found in SCA patients. Duodenal ulcer was commoner in males than females in both cases and controls with a ratio of 4:1 and 3.5:1 respectively. Only four (7.8%) SCA patients and one (2.4%) of controls had normal mucosa at histology, the rest had evidence of histological gastritis. We could not draw any correlation between non-steroidal anti-inflammatory drugs (NSAIDS) use and UGIT findings. Since the proportion of SCA cases with UGIT abnormalities was significantly high, we recommend that dyspeptic SCA patients undergo UGIT investigations including endoscopy to maximise their clinical care. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/9640811/Upper_gastrointestinal_mucosal_lesions_in_dyspeptic_patients_with_homozygous_sickle_cell_disease_in_Kenya_ L2 - http://www.diseaseinfosearch.org/result/6589 DB - PRIME DP - Unbound Medicine ER -