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Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity.
Biochem Biophys Res Commun. 1998 Jun 18; 247(2):217-22.BB

Abstract

By searching the Expressed Sequence Tag (EST) data base, we identified a partial cDNA sequence encoding a novel human CC chemokine. The entire cDNA sequence was determined and revealed a CC chemokine whose mature protein consisted of 100 amino acids with predicted molecular weight of 11 kd. The chemokine preferantially chemoattracted lymphocytes and monocytes but not neutrophils. It was, therefore, named LMC (Lymphocyte and Monocyte Chemoattractant). LMC exhibited potent myelosuppressive activity, which was comparable to that of MIP-1alpha. We identified several bacterial artificial clones (BAC) containing the LMC gene along with two human CC chemokine subfamily members; leukotactin-1 (Lkn-1) and CKbeta8-1/CKbeta8. This data suggests that the LMC gene is located at human chromosome 17q which encompasses a human CC chemokine gene cluster.

Authors+Show Affiliations

Department of Microbiology and Immunology, Department of Medicine, Walther Oncology Center, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana, 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9642106

Citation

Youn, B S., et al. "Isolation and Characterization of LMC, a Novel Lymphocyte and Monocyte Chemoattractant Human CC Chemokine, With Myelosuppressive Activity." Biochemical and Biophysical Research Communications, vol. 247, no. 2, 1998, pp. 217-22.
Youn BS, Zhang S, Broxmeyer HE, et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem Biophys Res Commun. 1998;247(2):217-22.
Youn, B. S., Zhang, S., Broxmeyer, H. E., Antol, K., Fraser, M. J., Hangoc, G., & Kwon, B. S. (1998). Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochemical and Biophysical Research Communications, 247(2), 217-22.
Youn BS, et al. Isolation and Characterization of LMC, a Novel Lymphocyte and Monocyte Chemoattractant Human CC Chemokine, With Myelosuppressive Activity. Biochem Biophys Res Commun. 1998 Jun 18;247(2):217-22. PubMed PMID: 9642106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. AU - Youn,B S, AU - Zhang,S, AU - Broxmeyer,H E, AU - Antol,K, AU - Fraser,M J,Jr AU - Hangoc,G, AU - Kwon,B S, PY - 1998/6/27/pubmed PY - 2001/3/28/medline PY - 1998/6/27/entrez SP - 217 EP - 22 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 247 IS - 2 N2 - By searching the Expressed Sequence Tag (EST) data base, we identified a partial cDNA sequence encoding a novel human CC chemokine. The entire cDNA sequence was determined and revealed a CC chemokine whose mature protein consisted of 100 amino acids with predicted molecular weight of 11 kd. The chemokine preferantially chemoattracted lymphocytes and monocytes but not neutrophils. It was, therefore, named LMC (Lymphocyte and Monocyte Chemoattractant). LMC exhibited potent myelosuppressive activity, which was comparable to that of MIP-1alpha. We identified several bacterial artificial clones (BAC) containing the LMC gene along with two human CC chemokine subfamily members; leukotactin-1 (Lkn-1) and CKbeta8-1/CKbeta8. This data suggests that the LMC gene is located at human chromosome 17q which encompasses a human CC chemokine gene cluster. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/9642106/Isolation_and_characterization_of_LMC_a_novel_lymphocyte_and_monocyte_chemoattractant_human_CC_chemokine_with_myelosuppressive_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(98)98762-9 DB - PRIME DP - Unbound Medicine ER -