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[AIDS-related cryptococcosis: diagnostic aspects, prognostic and therapeutic implications].
Ann Ital Med Int. 1998 Jan-Mar; 13(1):8-12.AI

Abstract

Diagnostic techniques of AIDS-related cryptococcosis were assessed in a series of 43 HIV-infected patients, and microbiological features were correlated to the clinical course and outcome of disease. Polysaccharide antigen detection was the most sensitive method for central nervous system infection, followed by direct microscopy and culture: in 4 patients this visceral mycosis was initially diagnosed by the detection of isolated cerebrospinal fluid antigen. Thirty-one patients out of 43 suffered from disseminated infection (with positive blood cultures and/or antigenemia). The occurrence of clinical relapses, a lethal outcome, and time to relapses or to death, did not differ significantly between patients with isolated central nervous system and those with disseminated cryptococcosis.

Authors+Show Affiliations

Manfredi R
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università degli Studi di Bologna.
Mazzoni A
No affiliation info available
Moroni A
No affiliation info available
Nanetti A
No affiliation info available
Donati M
No affiliation info available
Chiodo F
No affiliation info available

MeSH

AIDS-Related Opportunistic InfectionsAdolescentAdultChildCryptococcosisCryptococcus neoformansFemaleHumansMaleMiddle AgedPrognosisTreatment Outcome

Pub Type(s)

Journal Article

Language

ita

PubMed ID

9642836

Citation

Manfredi, R, et al. "[AIDS-related Cryptococcosis: Diagnostic Aspects, Prognostic and Therapeutic Implications]." Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, vol. 13, no. 1, 1998, pp. 8-12.
Manfredi R, Mazzoni A, Moroni A, et al. [AIDS-related cryptococcosis: diagnostic aspects, prognostic and therapeutic implications]. Ann Ital Med Int. 1998;13(1):8-12.
Manfredi, R., Mazzoni, A., Moroni, A., Nanetti, A., Donati, M., & Chiodo, F. (1998). [AIDS-related cryptococcosis: diagnostic aspects, prognostic and therapeutic implications]. Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, 13(1), 8-12.
Manfredi R, et al. [AIDS-related Cryptococcosis: Diagnostic Aspects, Prognostic and Therapeutic Implications]. Ann Ital Med Int. 1998 Jan-Mar;13(1):8-12. PubMed PMID: 9642836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [AIDS-related cryptococcosis: diagnostic aspects, prognostic and therapeutic implications]. AU - Manfredi,R, AU - Mazzoni,A, AU - Moroni,A, AU - Nanetti,A, AU - Donati,M, AU - Chiodo,F, PY - 1998/6/27/pubmed PY - 1998/6/27/medline PY - 1998/6/27/entrez SP - 8 EP - 12 JF - Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna JO - Ann Ital Med Int VL - 13 IS - 1 N2 - Diagnostic techniques of AIDS-related cryptococcosis were assessed in a series of 43 HIV-infected patients, and microbiological features were correlated to the clinical course and outcome of disease. Polysaccharide antigen detection was the most sensitive method for central nervous system infection, followed by direct microscopy and culture: in 4 patients this visceral mycosis was initially diagnosed by the detection of isolated cerebrospinal fluid antigen. Thirty-one patients out of 43 suffered from disseminated infection (with positive blood cultures and/or antigenemia). The occurrence of clinical relapses, a lethal outcome, and time to relapses or to death, did not differ significantly between patients with isolated central nervous system and those with disseminated cryptococcosis. SN - 0393-9340 UR - https://www.unboundmedicine.com/medline/citation/9642836/[AIDS_related_cryptococcosis:_diagnostic_aspects_prognostic_and_therapeutic_implications]_ DB - PRIME DP - Unbound Medicine ER -