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[The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures].
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr; 48(2):251-9.ZV

Abstract

Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT.

Authors+Show Affiliations

Trekova NA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Khlopushina TG
No affiliation info available
Basharova LA
No affiliation info available
Vetrilé LA
No affiliation info available
Mikovskaia OI
No affiliation info available
Evseev VA
No affiliation info available

MeSH

AnimalsAntibodiesBehavior, AnimalBiogenic MonoaminesBrain ChemistryDopamineHypothalamusImmunizationMaleMiceMice, Inbred C57BLMotor CortexRabbitsSerotoninTime Factors

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

rus

PubMed ID

9644805

Citation

Trekova, N A., et al. "[The Effect of Serotonin Antibodies On the Behavior of C57Bl/6 Mice in an Open Field and On the Level of Monoamines in the Brain Structures]." Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, vol. 48, no. 2, 1998, pp. 251-9.
Trekova NA, Khlopushina TG, Basharova LA, et al. [The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1998;48(2):251-9.
Trekova, N. A., Khlopushina, T. G., Basharova, L. A., Vetrilé, L. A., Mikovskaia, O. I., & Evseev, V. A. (1998). [The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures]. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, 48(2), 251-9.
Trekova NA, et al. [The Effect of Serotonin Antibodies On the Behavior of C57Bl/6 Mice in an Open Field and On the Level of Monoamines in the Brain Structures]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):251-9. PubMed PMID: 9644805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures]. AU - Trekova,N A, AU - Khlopushina,T G, AU - Basharova,L A, AU - Vetrilé,L A, AU - Mikovskaia,O I, AU - Evseev,V A, PY - 1998/6/30/pubmed PY - 1998/6/30/medline PY - 1998/6/30/entrez SP - 251 EP - 9 JF - Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova JO - Zh Vyssh Nerv Deiat Im I P Pavlova VL - 48 IS - 2 N2 - Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT. SN - 0044-4677 UR - https://www.unboundmedicine.com/medline/citation/9644805/[The_effect_of_serotonin_antibodies_on_the_behavior_of_C57Bl/6_mice_in_an_open_field_and_on_the_level_of_monoamines_in_the_brain_structures]_ DB - PRIME DP - Unbound Medicine ER -