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[Anticoagulant and fibrinolytic effects of proline-containing peptides].
Izv Akad Nauk Ser Biol. 1998 May-JunIA

Abstract

Anticoagulant, fibrinolytic, and fibrin-depolymerization effects were revealed during in vitro study of five proline-containing peptides (Gly-Pro, Trp-Pro, Pro-Gly, Gly-Pro-Gly-Gly, and Pro-Gly-Pro) in the concentration range 10(-9) to 10(-1) mg/ml. Intravenous injection of Trp-Pro and Pro-Gly into white rats at 250 micrograms/kg body weight significantly increased recalcification time and activated partial thromboplastin time of serum coagulation, increased fibrinolytic activity, decreased the level of serum factor XIII/(/)a and fibrinogen, and reduced thrombocyte aggregation. We propose inhibition of thromboplastin and thrombin formation in the serum by the studied proline-containing peptides both in vitro and in vivo.

Authors+Show Affiliations

Pastorova VE
Biology Faculty, Moscow State University, Moscow, Russia.
Liapina LA
No affiliation info available
Smolina TIu
No affiliation info available
Ashmarin IP
No affiliation info available

MeSH

AnimalsAnticoagulantsDipeptidesFibrinogenFibrinolytic AgentsHemostasisIn Vitro TechniquesInjections, IntravenousMaleOligopeptidesPartial Thromboplastin TimePlatelet AggregationPlatelet Aggregation InhibitorsProlineRatsTransglutaminases

Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

9644912

Citation

Pastorova, V E., et al. "[Anticoagulant and Fibrinolytic Effects of Proline-containing Peptides]." Izvestiia Akademii Nauk. Seriia Biologicheskaia, 1998, pp. 390-4.
Pastorova VE, Liapina LA, Smolina TIu, et al. [Anticoagulant and fibrinolytic effects of proline-containing peptides]. Izv Akad Nauk Ser Biol. 1998.
Pastorova, V. E., Liapina, L. A., Smolina, T. I. u., & Ashmarin, I. P. (1998). [Anticoagulant and fibrinolytic effects of proline-containing peptides]. Izvestiia Akademii Nauk. Seriia Biologicheskaia, (3), 390-4.
Pastorova VE, et al. [Anticoagulant and Fibrinolytic Effects of Proline-containing Peptides]. Izv Akad Nauk Ser Biol. 1998 May-Jun;(3)390-4. PubMed PMID: 9644912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anticoagulant and fibrinolytic effects of proline-containing peptides]. AU - Pastorova,V E, AU - Liapina,L A, AU - Smolina,T Iu, AU - Ashmarin,I P, PY - 1998/6/30/pubmed PY - 1998/6/30/medline PY - 1998/6/30/entrez SP - 390 EP - 4 JF - Izvestiia Akademii nauk. Seriia biologicheskaia JO - Izv Akad Nauk Ser Biol IS - 3 N2 - Anticoagulant, fibrinolytic, and fibrin-depolymerization effects were revealed during in vitro study of five proline-containing peptides (Gly-Pro, Trp-Pro, Pro-Gly, Gly-Pro-Gly-Gly, and Pro-Gly-Pro) in the concentration range 10(-9) to 10(-1) mg/ml. Intravenous injection of Trp-Pro and Pro-Gly into white rats at 250 micrograms/kg body weight significantly increased recalcification time and activated partial thromboplastin time of serum coagulation, increased fibrinolytic activity, decreased the level of serum factor XIII/(/)a and fibrinogen, and reduced thrombocyte aggregation. We propose inhibition of thromboplastin and thrombin formation in the serum by the studied proline-containing peptides both in vitro and in vivo. SN - 1026-3470 UR - https://www.unboundmedicine.com/medline/citation/9644912/[Anticoagulant_and_fibrinolytic_effects_of_proline_containing_peptides]_ L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -