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Results from an international case-control study of childhood brain tumors: the role of prenatal vitamin supplementation.
Environ Health Perspect. 1998 Jun; 106 Suppl 3:887-92.EH

Abstract

An international case-control study of primary pediatric brain tumors included interviews with mothers of cases diagnosed from 1976 to 1994 and mothers of population controls. Data are available on maternal vitamin use during pregnancy for 1051 cases and 1919 controls from eight geographic areas in North America, Europe, and Israel. Although risk estimates varied by study center, combined results suggest that maternal supplementation for two trimesters may decrease risk of brain tumor (odds ratio [OR] 0.7, 95% confidence interval [CI] 0.5-0.9), with a trend of less risk with longer duration of use (p trend = 0.0007). The greatest risk reduction was among children diagnosed under 5 years of age whose mothers used supplements during all three trimesters (OR 0.5, CI 0.3-0.8). This effect did not vary by histology and was seen for supplementation during pregnancy rather than during the month before pregnancy or while breast feeding. These findings are largely driven by data from the United States, where most mothers took vitamins. The proportion of control mothers who took vitamins during pregnancy varied tremendously: from 3% in Israel and France, 21% in Italy, 33% in Canada, 52% in Spain and 86 to 92% at the three U.S. centers. The composition of the various multivitamin compounds taken also varied: the daily dose of vitamin C ranged from 0 to 600 mg, vitamin E ranged from 0 to 70 mg, vitamin A ranged from 0 to 30,000 IU, and folate ranged from 0 to 2000 micrograms. Mothers also took individual micronutrient supplements (e.g., vitamin C tablets), but most mothers who took these also took multivitamins, making it impossible to determine potential independent effects of these micronutrients.

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California, Los Angeles, USA. spresto@hsc.usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9646053

Citation

Preston-Martin, S, et al. "Results From an International Case-control Study of Childhood Brain Tumors: the Role of Prenatal Vitamin Supplementation." Environmental Health Perspectives, vol. 106 Suppl 3, 1998, pp. 887-92.
Preston-Martin S, Pogoda JM, Mueller BA, et al. Results from an international case-control study of childhood brain tumors: the role of prenatal vitamin supplementation. Environ Health Perspect. 1998;106 Suppl 3:887-92.
Preston-Martin, S., Pogoda, J. M., Mueller, B. A., Lubin, F., Modan, B., Holly, E. A., Filippini, G., Cordier, S., Peris-Bonet, R., Choi, W., Little, J., & Arslan, A. (1998). Results from an international case-control study of childhood brain tumors: the role of prenatal vitamin supplementation. Environmental Health Perspectives, 106 Suppl 3, 887-92.
Preston-Martin S, et al. Results From an International Case-control Study of Childhood Brain Tumors: the Role of Prenatal Vitamin Supplementation. Environ Health Perspect. 1998;106 Suppl 3:887-92. PubMed PMID: 9646053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Results from an international case-control study of childhood brain tumors: the role of prenatal vitamin supplementation. AU - Preston-Martin,S, AU - Pogoda,J M, AU - Mueller,B A, AU - Lubin,F, AU - Modan,B, AU - Holly,E A, AU - Filippini,G, AU - Cordier,S, AU - Peris-Bonet,R, AU - Choi,W, AU - Little,J, AU - Arslan,A, PY - 1998/7/1/pubmed PY - 1998/7/1/medline PY - 1998/7/1/entrez SP - 887 EP - 92 JF - Environmental health perspectives JO - Environ Health Perspect VL - 106 Suppl 3 N2 - An international case-control study of primary pediatric brain tumors included interviews with mothers of cases diagnosed from 1976 to 1994 and mothers of population controls. Data are available on maternal vitamin use during pregnancy for 1051 cases and 1919 controls from eight geographic areas in North America, Europe, and Israel. Although risk estimates varied by study center, combined results suggest that maternal supplementation for two trimesters may decrease risk of brain tumor (odds ratio [OR] 0.7, 95% confidence interval [CI] 0.5-0.9), with a trend of less risk with longer duration of use (p trend = 0.0007). The greatest risk reduction was among children diagnosed under 5 years of age whose mothers used supplements during all three trimesters (OR 0.5, CI 0.3-0.8). This effect did not vary by histology and was seen for supplementation during pregnancy rather than during the month before pregnancy or while breast feeding. These findings are largely driven by data from the United States, where most mothers took vitamins. The proportion of control mothers who took vitamins during pregnancy varied tremendously: from 3% in Israel and France, 21% in Italy, 33% in Canada, 52% in Spain and 86 to 92% at the three U.S. centers. The composition of the various multivitamin compounds taken also varied: the daily dose of vitamin C ranged from 0 to 600 mg, vitamin E ranged from 0 to 70 mg, vitamin A ranged from 0 to 30,000 IU, and folate ranged from 0 to 2000 micrograms. Mothers also took individual micronutrient supplements (e.g., vitamin C tablets), but most mothers who took these also took multivitamins, making it impossible to determine potential independent effects of these micronutrients. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/9646053/Results_from_an_international_case_control_study_of_childhood_brain_tumors:_the_role_of_prenatal_vitamin_supplementation_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.98106887?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -