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Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO).
Ital J Gastroenterol Hepatol 1997; 29(3):249-54IJ

Abstract

AIMS

To investigate the incidence, risk factors and natural history of gallstone disease, a random sample of females belonging to a rural population was enrolled in a ten-year longitudinal study.

METHODS

The study has been performed in a small town on the hills south of Rome. In 1985, a random sample of 426 females, aged 20-69 years, was screened by real-time ultrasonography for gallstones and previous cholecystectomy. Screening methods included anthropometry, collection of a blood sample and a questionnaire on the occurrence of abdominal symptoms. During 1995, all these subjects were invited for a 10-year follow-up examination.

RESULTS

The overall 10-year incidence of gallstone disease was 6.3% (5.5% of new gallstones and 0.8% of cholecystectomies). Only 23.1% of the women with gallstones were aware of their condition. More than three quarters (76.9%) had not suffered biliary pain. Univariate and multivariate analyses demonstrated a positive independent association of new gallstone disease with body mass index and parity. Out of the initially asymptomatic gallstone women, 15.4% experienced at least one episode of biliary pain, 23.1% were submitted to elective cholecystectomy and 61.5% remained asymptomatic.

CONCLUSIONS

The study demonstrates a high incidence of gallstone disease in women belonging to a rural free-living population in Italy and suggests body mass index and parity as possible true risk factors. Moreover, it confirms that a remarkable proportion of asymptomatic patients become symptomatic and eventually undergo cholecystectomy.

Authors+Show Affiliations

Institute of Systematic Medical Therapy, University La Sapienza, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9646217

Citation

Angelico, F, et al. "Ten-year Incidence and Natural History of Gallstone Disease in a Rural Population of Women in Central Italy. the Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO)." Italian Journal of Gastroenterology and Hepatology, vol. 29, no. 3, 1997, pp. 249-54.
Angelico F, Del Ben M, Barbato A, et al. Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Ital J Gastroenterol Hepatol. 1997;29(3):249-54.
Angelico, F., Del Ben, M., Barbato, A., Conti, R., & Urbinati, G. (1997). Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Italian Journal of Gastroenterology and Hepatology, 29(3), pp. 249-54.
Angelico F, et al. Ten-year Incidence and Natural History of Gallstone Disease in a Rural Population of Women in Central Italy. the Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Ital J Gastroenterol Hepatol. 1997;29(3):249-54. PubMed PMID: 9646217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). AU - Angelico,F, AU - Del Ben,M, AU - Barbato,A, AU - Conti,R, AU - Urbinati,G, PY - 1997/6/1/pubmed PY - 1998/7/1/medline PY - 1997/6/1/entrez SP - 249 EP - 54 JF - Italian journal of gastroenterology and hepatology JO - Ital J Gastroenterol Hepatol VL - 29 IS - 3 N2 - AIMS: To investigate the incidence, risk factors and natural history of gallstone disease, a random sample of females belonging to a rural population was enrolled in a ten-year longitudinal study. METHODS: The study has been performed in a small town on the hills south of Rome. In 1985, a random sample of 426 females, aged 20-69 years, was screened by real-time ultrasonography for gallstones and previous cholecystectomy. Screening methods included anthropometry, collection of a blood sample and a questionnaire on the occurrence of abdominal symptoms. During 1995, all these subjects were invited for a 10-year follow-up examination. RESULTS: The overall 10-year incidence of gallstone disease was 6.3% (5.5% of new gallstones and 0.8% of cholecystectomies). Only 23.1% of the women with gallstones were aware of their condition. More than three quarters (76.9%) had not suffered biliary pain. Univariate and multivariate analyses demonstrated a positive independent association of new gallstone disease with body mass index and parity. Out of the initially asymptomatic gallstone women, 15.4% experienced at least one episode of biliary pain, 23.1% were submitted to elective cholecystectomy and 61.5% remained asymptomatic. CONCLUSIONS: The study demonstrates a high incidence of gallstone disease in women belonging to a rural free-living population in Italy and suggests body mass index and parity as possible true risk factors. Moreover, it confirms that a remarkable proportion of asymptomatic patients become symptomatic and eventually undergo cholecystectomy. SN - 1125-8055 UR - https://www.unboundmedicine.com/medline/citation/9646217/Ten_year_incidence_and_natural_history_of_gallstone_disease_in_a_rural_population_of_women_in_central_Italy__The_Rome_Group_for_the_Epidemiology_and_Prevention_of_Cholelithiasis__GREPCO__ L2 - http://www.diseaseinfosearch.org/result/7025 DB - PRIME DP - Unbound Medicine ER -