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Esophageal manometry and ambulatory 24-hour pH monitoring in patients with short and long segment Barrett's esophagus.
Am J Gastroenterol. 1998 Jun; 93(6):916-9.AJ

Abstract

OBJECTIVE

Short segment Barrett's esophagus (SSBE) is defined as the presence of specialized intestinal metaplasia (SIM) in the distal 2-3 cm of the esophagus. Although gastroesophageal reflux and heartburn is very common in these patients, the pathophysiology of the development of a short segment of SIM versus a longer segment of Barrett's epithelium is not clear. The aim of this study was to assess the extent of gastroesophageal reflux in short versus long segments of SIM.

METHODS

Of 203 consecutive patients undergoing endoscopy with two biopsies performed just distal to the squamocolumnar junction, 28 patients were identified as having SSBE as evidenced by SIM on biopsy. Twenty-two SSBE patients underwent esophageal manometry and 24-h dual pH monitoring, and the results were compared with 18 long segment Barrett's esophagus (LSBE) patients and 15 patients with normal 24-h pH studies.

RESULTS

SSBE and LSBE patients were significantly older than normal subjects (p < 0.0001). Also, lower esophageal sphincter pressure was significantly greater in SSBE patients compared with LSBE patients (12.3 +/- 1.6 vs 5.2 +/- 1.0 mm Hg,p < 0.0008). LSBE patients had a significantly lower distal esophageal peristaltic amplitude as compared with normals (p < 0.012). At 5 cm proximal to the LES, SSBE patients had significantly lower total 24-h pH scores, percent upright and percent supine reflux as compared with LSBE patients. Similarly, when measured at the proximal LES (0 cm), SSBE patients had significantly lower 24-h pH scores when compared with LSBE patients (p < 0.03), whereas percent upright and percent supine reflux were not significantly different. Both LSBE and SSBE patients had a greater degree of GER measured at 5 cm above and just proximal to the LES when compared with normals.

CONCLUSION

As a group, SSBE patients have more competent LES sphincters and less gastroesophageal reflux at 0 and 5 cm above the LES as compared with patients with LSBE. These data indicate that the degree and length of acid exposure in the esophagus are important factors in the pathogenesis of SIM involvement of the esophagus.

Authors+Show Affiliations

Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9647018

Citation

Loughney, T, et al. "Esophageal Manometry and Ambulatory 24-hour pH Monitoring in Patients With Short and Long Segment Barrett's Esophagus." The American Journal of Gastroenterology, vol. 93, no. 6, 1998, pp. 916-9.
Loughney T, Maydonovitch CL, Wong RK. Esophageal manometry and ambulatory 24-hour pH monitoring in patients with short and long segment Barrett's esophagus. Am J Gastroenterol. 1998;93(6):916-9.
Loughney, T., Maydonovitch, C. L., & Wong, R. K. (1998). Esophageal manometry and ambulatory 24-hour pH monitoring in patients with short and long segment Barrett's esophagus. The American Journal of Gastroenterology, 93(6), 916-9.
Loughney T, Maydonovitch CL, Wong RK. Esophageal Manometry and Ambulatory 24-hour pH Monitoring in Patients With Short and Long Segment Barrett's Esophagus. Am J Gastroenterol. 1998;93(6):916-9. PubMed PMID: 9647018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Esophageal manometry and ambulatory 24-hour pH monitoring in patients with short and long segment Barrett's esophagus. AU - Loughney,T, AU - Maydonovitch,C L, AU - Wong,R K, PY - 1998/7/1/pubmed PY - 1998/7/1/medline PY - 1998/7/1/entrez SP - 916 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 93 IS - 6 N2 - OBJECTIVE: Short segment Barrett's esophagus (SSBE) is defined as the presence of specialized intestinal metaplasia (SIM) in the distal 2-3 cm of the esophagus. Although gastroesophageal reflux and heartburn is very common in these patients, the pathophysiology of the development of a short segment of SIM versus a longer segment of Barrett's epithelium is not clear. The aim of this study was to assess the extent of gastroesophageal reflux in short versus long segments of SIM. METHODS: Of 203 consecutive patients undergoing endoscopy with two biopsies performed just distal to the squamocolumnar junction, 28 patients were identified as having SSBE as evidenced by SIM on biopsy. Twenty-two SSBE patients underwent esophageal manometry and 24-h dual pH monitoring, and the results were compared with 18 long segment Barrett's esophagus (LSBE) patients and 15 patients with normal 24-h pH studies. RESULTS: SSBE and LSBE patients were significantly older than normal subjects (p < 0.0001). Also, lower esophageal sphincter pressure was significantly greater in SSBE patients compared with LSBE patients (12.3 +/- 1.6 vs 5.2 +/- 1.0 mm Hg,p < 0.0008). LSBE patients had a significantly lower distal esophageal peristaltic amplitude as compared with normals (p < 0.012). At 5 cm proximal to the LES, SSBE patients had significantly lower total 24-h pH scores, percent upright and percent supine reflux as compared with LSBE patients. Similarly, when measured at the proximal LES (0 cm), SSBE patients had significantly lower 24-h pH scores when compared with LSBE patients (p < 0.03), whereas percent upright and percent supine reflux were not significantly different. Both LSBE and SSBE patients had a greater degree of GER measured at 5 cm above and just proximal to the LES when compared with normals. CONCLUSION: As a group, SSBE patients have more competent LES sphincters and less gastroesophageal reflux at 0 and 5 cm above the LES as compared with patients with LSBE. These data indicate that the degree and length of acid exposure in the esophagus are important factors in the pathogenesis of SIM involvement of the esophagus. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9647018/Esophageal_manometry_and_ambulatory_24_hour_pH_monitoring_in_patients_with_short_and_long_segment_Barrett's_esophagus_ L2 - http://Insights.ovid.com/pubmed?pmid=9647018 DB - PRIME DP - Unbound Medicine ER -