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Curcumin attenuation of acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun; 124(3):425-7.BJ

Abstract

The protective effect of curcumin on acute adriamycin (ADR) myocardial toxicity was analysed in rats. ADR toxicity, induced by a single intraperitoneal injection (30 mg kg(-1)), was revealed by elevated serum creatine kinase (CK) and lactate dehydrogenase (LDH). The level of the lipid peroxidation products, conjugated dienes and malondialdehyde, was markedly elevated by ADR. ADR caused a decrease in myocardial glutathione content and glutathione peroxidase activity. In contrast, cardiac catalase activity was increased in ADR rats. Curcumin treatment (200 mg kg(-1), seven days before and two days following ADR) significantly ameliorated the early manifestation of cardiotoxicity (ST segment elevation and an increase in heart rate) and prevented the rise in serum CK and LDH exerted by ADR. ADR rats that received curcumin displayed a significant inhibition of lipid peroxidation and augmentation of endogenous antioxidants. These results suggest that curcumin inhibits ADR cardiotoxicity and might serve as novel combination chemotherapeutic agent with ADR to limit free radical-mediated organ injury.

Authors+Show Affiliations

Department of Biochemistry, Central Leather Research Institute, Madras, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9647462

Citation

Venkatesan, N. "Curcumin Attenuation of Acute Adriamycin Myocardial Toxicity in Rats." British Journal of Pharmacology, vol. 124, no. 3, 1998, pp. 425-7.
Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol. 1998;124(3):425-7.
Venkatesan, N. (1998). Curcumin attenuation of acute adriamycin myocardial toxicity in rats. British Journal of Pharmacology, 124(3), 425-7.
Venkatesan N. Curcumin Attenuation of Acute Adriamycin Myocardial Toxicity in Rats. Br J Pharmacol. 1998;124(3):425-7. PubMed PMID: 9647462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin attenuation of acute adriamycin myocardial toxicity in rats. A1 - Venkatesan,N, PY - 1998/7/1/pubmed PY - 1998/7/1/medline PY - 1998/7/1/entrez SP - 425 EP - 7 JF - British journal of pharmacology JO - Br J Pharmacol VL - 124 IS - 3 N2 - The protective effect of curcumin on acute adriamycin (ADR) myocardial toxicity was analysed in rats. ADR toxicity, induced by a single intraperitoneal injection (30 mg kg(-1)), was revealed by elevated serum creatine kinase (CK) and lactate dehydrogenase (LDH). The level of the lipid peroxidation products, conjugated dienes and malondialdehyde, was markedly elevated by ADR. ADR caused a decrease in myocardial glutathione content and glutathione peroxidase activity. In contrast, cardiac catalase activity was increased in ADR rats. Curcumin treatment (200 mg kg(-1), seven days before and two days following ADR) significantly ameliorated the early manifestation of cardiotoxicity (ST segment elevation and an increase in heart rate) and prevented the rise in serum CK and LDH exerted by ADR. ADR rats that received curcumin displayed a significant inhibition of lipid peroxidation and augmentation of endogenous antioxidants. These results suggest that curcumin inhibits ADR cardiotoxicity and might serve as novel combination chemotherapeutic agent with ADR to limit free radical-mediated organ injury. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/9647462/Curcumin_attenuation_of_acute_adriamycin_myocardial_toxicity_in_rats_ L2 - https://doi.org/10.1038/sj.bjp.0701877 DB - PRIME DP - Unbound Medicine ER -