Tags

Type your tag names separated by a space and hit enter

Telomerase activity in benign and malignant human thyroid tissues.
Br J Cancer. 1998 Jun; 77(12):2177-80.BJ

Abstract

Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomerase activity plays a role in carcinogenesis and immortalization. In this work, the status of telomerase activity during the development of human thyroid cancer was determined using telomeric repeat amplification protocol (TRAP) in 14 nodular hyperplasia, 14 adenomas, 23 papillary carcinomas and 11 follicular carcinomas. Positive telomerase activity was detected in 2 of 14 nodular hyperplasias (14%), 4 of 14 adenomas (29%), 12 of 23 papillary carcinomas (52%) and 10 of 11 follicular carcinomas (91%). The cancers that are negative for telomerase activity are mostly in early stage (stage I or II). These results suggest that telomerase reactivation plays a role during the development of thyroid cancer.

Authors+Show Affiliations

Department of Molecular and Cellular Biology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9649130

Citation

Cheng, A J., et al. "Telomerase Activity in Benign and Malignant Human Thyroid Tissues." British Journal of Cancer, vol. 77, no. 12, 1998, pp. 2177-80.
Cheng AJ, Lin JD, Chang T, et al. Telomerase activity in benign and malignant human thyroid tissues. Br J Cancer. 1998;77(12):2177-80.
Cheng, A. J., Lin, J. D., Chang, T., & Wang, T. C. (1998). Telomerase activity in benign and malignant human thyroid tissues. British Journal of Cancer, 77(12), 2177-80.
Cheng AJ, et al. Telomerase Activity in Benign and Malignant Human Thyroid Tissues. Br J Cancer. 1998;77(12):2177-80. PubMed PMID: 9649130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity in benign and malignant human thyroid tissues. AU - Cheng,A J, AU - Lin,J D, AU - Chang,T, AU - Wang,T C, PY - 1998/7/2/pubmed PY - 1998/7/2/medline PY - 1998/7/2/entrez SP - 2177 EP - 80 JF - British journal of cancer JO - Br J Cancer VL - 77 IS - 12 N2 - Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomerase activity plays a role in carcinogenesis and immortalization. In this work, the status of telomerase activity during the development of human thyroid cancer was determined using telomeric repeat amplification protocol (TRAP) in 14 nodular hyperplasia, 14 adenomas, 23 papillary carcinomas and 11 follicular carcinomas. Positive telomerase activity was detected in 2 of 14 nodular hyperplasias (14%), 4 of 14 adenomas (29%), 12 of 23 papillary carcinomas (52%) and 10 of 11 follicular carcinomas (91%). The cancers that are negative for telomerase activity are mostly in early stage (stage I or II). These results suggest that telomerase reactivation plays a role during the development of thyroid cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/9649130/Telomerase_activity_in_benign_and_malignant_human_thyroid_tissues_ L2 - https://doi.org/10.1038/bjc.1998.363 DB - PRIME DP - Unbound Medicine ER -