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RETRACTED ARTICLE

Effective dose of granisetron for the prevention of post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
Eur J Anaesthesiol. 1998 May; 15(3):287-91.EJ

Abstract

This study was undertaken to determine the minimum effective dose of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, for the prevention of post-operative nausea and vomiting (PONV) in female patients undergoing elective laparoscopic cholecystectomy. In randomized, placebo-controlled, double-blind study, 120 women were assigned to receive either placebo (saline) or granisetron at three different doses (20 micrograms kg-1, 40 micrograms kg-1 or 80 micrograms kg-1) intravenously immediately before the induction of anaesthesia. All patients received standardized anaesthesia consisting of isoflurane and nitrous oxide in oxygen. The incidence of PONV during the first 24 hours after anaesthesia was 43, 40, 13 and 13% after administration of placebo and granisetron 20 micrograms kg-1, 40 micrograms kg-1 and 80 micrograms kg-1, respectively (P < 0.05, overall Fisher's exact probability test). Adverse effects post-operatively were not different among the groups. In conclusion, granisetron 40 micrograms kg-1 is the minimum effective dose in the prevention of PONV after laparoscopic cholecystectomy.

Authors+Show Affiliations

Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9649986

Citation

Fujii, Y, et al. "Effective Dose of Granisetron for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy." European Journal of Anaesthesiology, vol. 15, no. 3, 1998, pp. 287-91.
Fujii Y, Saitoh Y, Tanaka H, et al. Effective dose of granisetron for the prevention of post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Eur J Anaesthesiol. 1998;15(3):287-91.
Fujii, Y., Saitoh, Y., Tanaka, H., & Toyooka, H. (1998). Effective dose of granisetron for the prevention of post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. European Journal of Anaesthesiology, 15(3), 287-91.
Fujii Y, et al. Effective Dose of Granisetron for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy. Eur J Anaesthesiol. 1998;15(3):287-91. PubMed PMID: 9649986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effective dose of granisetron for the prevention of post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. AU - Fujii,Y, AU - Saitoh,Y, AU - Tanaka,H, AU - Toyooka,H, PY - 1998/7/3/pubmed PY - 1998/7/3/medline PY - 1998/7/3/entrez SP - 287 EP - 91 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 15 IS - 3 N2 - This study was undertaken to determine the minimum effective dose of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, for the prevention of post-operative nausea and vomiting (PONV) in female patients undergoing elective laparoscopic cholecystectomy. In randomized, placebo-controlled, double-blind study, 120 women were assigned to receive either placebo (saline) or granisetron at three different doses (20 micrograms kg-1, 40 micrograms kg-1 or 80 micrograms kg-1) intravenously immediately before the induction of anaesthesia. All patients received standardized anaesthesia consisting of isoflurane and nitrous oxide in oxygen. The incidence of PONV during the first 24 hours after anaesthesia was 43, 40, 13 and 13% after administration of placebo and granisetron 20 micrograms kg-1, 40 micrograms kg-1 and 80 micrograms kg-1, respectively (P < 0.05, overall Fisher's exact probability test). Adverse effects post-operatively were not different among the groups. In conclusion, granisetron 40 micrograms kg-1 is the minimum effective dose in the prevention of PONV after laparoscopic cholecystectomy. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/9649986/Effective_dose_of_granisetron_for_the_prevention_of_post_operative_nausea_and_vomiting_in_patients_undergoing_laparoscopic_cholecystectomy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9649986.ui DB - PRIME DP - Unbound Medicine ER -