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[The effect of 4 years' of hypolipemic treatment on the width of the common carotid artery intima in patients with familial hyperlipidemias].
Vnitr Lek. 1997 Nov; 43(11):722-7.VL

Abstract

Sixty-four patients with familial hyperlipoproteinaemia were treated for almost four years by dietetic treatment and various hypolipidaemic drugs. In 25 patients with familial hypercholesterolaemia who had clinical signs of ischaemic heart disease total and LDL-cholesterol declined and the width of the intima of the common carotid artery diminished from 0.78 mm to 0.69 mm (p = 0.004). In the above artery the maximal flow rate of blood declined. The increase was, however, not statistically significant. In 12 patients with familial hypercholesterolaemia who suffered from ischaemic heart disease the width of the intima of the common carotid artery and maximum flow rate did not change, however, the diameter of the artery increased (from 6.3 to 6.6 mm, p = 0.034). In 27 patients with familial combined hyperlipidaemia during the drop of cholesterol, LDL-cholesterol and triacylglycerols the width of the intima of the common carotid artery diminished (from 0.72 to 0.67 mm, p = 0.044), the diameter of the artery increased (from 6.1 to 6.4 mm, p = 0.014). The authors assume that the reduction of the width of the intima during hypolipidaemic treatment reflected the decline of cholesterol in the arterial wall and is a favourable sign which indicates possible regression of atherosclerosis.

Authors+Show Affiliations

III. interní klinika VFN a 1. LF UK, Praha.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

9650502

Citation

Spácil, J, et al. "[The Effect of 4 Years' of Hypolipemic Treatment On the Width of the Common Carotid Artery Intima in Patients With Familial Hyperlipidemias]." Vnitrni Lekarstvi, vol. 43, no. 11, 1997, pp. 722-7.
Spácil J, Ceska R, Petrásek J, et al. [The effect of 4 years' of hypolipemic treatment on the width of the common carotid artery intima in patients with familial hyperlipidemias]. Vnitr Lek. 1997;43(11):722-7.
Spácil, J., Ceska, R., Petrásek, J., & Sobra, J. (1997). [The effect of 4 years' of hypolipemic treatment on the width of the common carotid artery intima in patients with familial hyperlipidemias]. Vnitrni Lekarstvi, 43(11), 722-7.
Spácil J, et al. [The Effect of 4 Years' of Hypolipemic Treatment On the Width of the Common Carotid Artery Intima in Patients With Familial Hyperlipidemias]. Vnitr Lek. 1997;43(11):722-7. PubMed PMID: 9650502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of 4 years' of hypolipemic treatment on the width of the common carotid artery intima in patients with familial hyperlipidemias]. AU - Spácil,J, AU - Ceska,R, AU - Petrásek,J, AU - Sobra,J, PY - 1998/7/3/pubmed PY - 1998/7/3/medline PY - 1998/7/3/entrez SP - 722 EP - 7 JF - Vnitrni lekarstvi JO - Vnitr Lek VL - 43 IS - 11 N2 - Sixty-four patients with familial hyperlipoproteinaemia were treated for almost four years by dietetic treatment and various hypolipidaemic drugs. In 25 patients with familial hypercholesterolaemia who had clinical signs of ischaemic heart disease total and LDL-cholesterol declined and the width of the intima of the common carotid artery diminished from 0.78 mm to 0.69 mm (p = 0.004). In the above artery the maximal flow rate of blood declined. The increase was, however, not statistically significant. In 12 patients with familial hypercholesterolaemia who suffered from ischaemic heart disease the width of the intima of the common carotid artery and maximum flow rate did not change, however, the diameter of the artery increased (from 6.3 to 6.6 mm, p = 0.034). In 27 patients with familial combined hyperlipidaemia during the drop of cholesterol, LDL-cholesterol and triacylglycerols the width of the intima of the common carotid artery diminished (from 0.72 to 0.67 mm, p = 0.044), the diameter of the artery increased (from 6.1 to 6.4 mm, p = 0.014). The authors assume that the reduction of the width of the intima during hypolipidaemic treatment reflected the decline of cholesterol in the arterial wall and is a favourable sign which indicates possible regression of atherosclerosis. SN - 0042-773X UR - https://www.unboundmedicine.com/medline/citation/9650502/[The_effect_of_4_years'_of_hypolipemic_treatment_on_the_width_of_the_common_carotid_artery_intima_in_patients_with_familial_hyperlipidemias]_ DB - PRIME DP - Unbound Medicine ER -