Tags

Type your tag names separated by a space and hit enter

Hyperinsulinemia and carotid atherosclerosis in hypertensive and control subjects.
Diabetes Care 1998; 21(7):1188-93DC

Abstract

OBJECTIVE

To analyze the relationships between carotid atherosclerosis measured as intima-media thickness (IMT) and different measures of insulin in a population-based case-control study of men and women.

RESEARCH DESIGN AND METHODS

Carotid ultrasonographic measurements and 2-h oral glucose tolerance tests were performed in a random sample of 513 hypertensive subjects, aged 40-59 years, and in 518 age- and sex-matched control subjects. The associations between IMT and the different measures of insulin were analyzed through multiple regression and by insulin quintiles. The independent effect of insulin was estimated after concurrent adjustment for age, obesity, LDL cholesterol, and systolic blood pressure.

RESULTS

The most powerful correlates with IMT were LDL cholesterol, age, systolic blood pressure, pack-years of smoking, and of the different insulin parameters, 2-h post-load insulin. In stepwise regression analysis, the independent predictors of the mean IMT were LDL cholesterol, systolic blood pressure, pack-years of smoking, and age (P < 0.0001) after adjustment for the independent predictors. In analysis of variance, no positive association of insulin parameters with IMT was found between the 2-h insulin quintiles after adjustment for the independent variables. The exclusion of diabetic subjects did not change the results.

CONCLUSIONS

The present study of a population-based sample of men and women found inconsistent associations between different insulin measures and IMT after adjustment for the independent variables.

Authors+Show Affiliations

Department of Internal Medicine, University of Oulu, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9653618

Citation

Rantala, A O., et al. "Hyperinsulinemia and Carotid Atherosclerosis in Hypertensive and Control Subjects." Diabetes Care, vol. 21, no. 7, 1998, pp. 1188-93.
Rantala AO, Päivänsalo M, Kauma H, et al. Hyperinsulinemia and carotid atherosclerosis in hypertensive and control subjects. Diabetes Care. 1998;21(7):1188-93.
Rantala, A. O., Päivänsalo, M., Kauma, H., Lilja, M., Savolainen, M. J., Reunanen, A., & Kesäniemi, Y. A. (1998). Hyperinsulinemia and carotid atherosclerosis in hypertensive and control subjects. Diabetes Care, 21(7), pp. 1188-93.
Rantala AO, et al. Hyperinsulinemia and Carotid Atherosclerosis in Hypertensive and Control Subjects. Diabetes Care. 1998;21(7):1188-93. PubMed PMID: 9653618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperinsulinemia and carotid atherosclerosis in hypertensive and control subjects. AU - Rantala,A O, AU - Päivänsalo,M, AU - Kauma,H, AU - Lilja,M, AU - Savolainen,M J, AU - Reunanen,A, AU - Kesäniemi,Y A, PY - 1998/7/8/pubmed PY - 1998/7/8/medline PY - 1998/7/8/entrez SP - 1188 EP - 93 JF - Diabetes care JO - Diabetes Care VL - 21 IS - 7 N2 - OBJECTIVE: To analyze the relationships between carotid atherosclerosis measured as intima-media thickness (IMT) and different measures of insulin in a population-based case-control study of men and women. RESEARCH DESIGN AND METHODS: Carotid ultrasonographic measurements and 2-h oral glucose tolerance tests were performed in a random sample of 513 hypertensive subjects, aged 40-59 years, and in 518 age- and sex-matched control subjects. The associations between IMT and the different measures of insulin were analyzed through multiple regression and by insulin quintiles. The independent effect of insulin was estimated after concurrent adjustment for age, obesity, LDL cholesterol, and systolic blood pressure. RESULTS: The most powerful correlates with IMT were LDL cholesterol, age, systolic blood pressure, pack-years of smoking, and of the different insulin parameters, 2-h post-load insulin. In stepwise regression analysis, the independent predictors of the mean IMT were LDL cholesterol, systolic blood pressure, pack-years of smoking, and age (P < 0.0001) after adjustment for the independent predictors. In analysis of variance, no positive association of insulin parameters with IMT was found between the 2-h insulin quintiles after adjustment for the independent variables. The exclusion of diabetic subjects did not change the results. CONCLUSIONS: The present study of a population-based sample of men and women found inconsistent associations between different insulin measures and IMT after adjustment for the independent variables. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/9653618/Hyperinsulinemia_and_carotid_atherosclerosis_in_hypertensive_and_control_subjects_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9653618.ui DB - PRIME DP - Unbound Medicine ER -