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A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.
Genomics. 1998 Jun 01; 50(2):121-8.G

Abstract

We completed a systematic survey of the human genome, conducted at an average resolution of 10 cM, for the identification of simple sequence tandem repeat polymorphisms (SSTRPs) that target new risk genes for Alzheimer disease (AD) by virtue of linkage disequilibrium. The efficiency of our association study was enhanced by genotyping pools of DNA from autopsy-confirmed cases with AD and matched controls. Allelic associations with AD were observed for 6 of the 391 SSTRPs in the CHLC Human Screening Set/Weber Version 6 (Research Genetics, Inc., Huntsville, AL): D1S518, D1S547, D10S1423, D12S1045, D19S178, and DXS1047. These allelic associations were replicated in an independent sample of autopsied AD cases and controls recruited from a geographically disparate site. The association of the large D19S178 alleles with AD appeared to arise from linkage disequilibrium with the APOE epsilon 4 allele, whose effect on increasing the risk of AD has been established. None of the remaining SSTRPs was in close proximity to loci previously reported to influence the risk of developing AD. Instead, they may identify five novel AD susceptibility loci.

Authors+Show Affiliations

Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania 15260, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9653640

Citation

Zubenko, G S., et al. "A Genome Survey for Novel Alzheimer Disease Risk Loci: Results at 10-cM Resolution." Genomics, vol. 50, no. 2, 1998, pp. 121-8.
Zubenko GS, Hughes HB, Stiffler JS, et al. A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. Genomics. 1998;50(2):121-8.
Zubenko, G. S., Hughes, H. B., Stiffler, J. S., Hurtt, M. R., & Kaplan, B. B. (1998). A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. Genomics, 50(2), 121-8.
Zubenko GS, et al. A Genome Survey for Novel Alzheimer Disease Risk Loci: Results at 10-cM Resolution. Genomics. 1998 Jun 1;50(2):121-8. PubMed PMID: 9653640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. AU - Zubenko,G S, AU - Hughes,H B, AU - Stiffler,J S, AU - Hurtt,M R, AU - Kaplan,B B, PY - 1998/7/8/pubmed PY - 1998/7/8/medline PY - 1998/7/8/entrez SP - 121 EP - 8 JF - Genomics JO - Genomics VL - 50 IS - 2 N2 - We completed a systematic survey of the human genome, conducted at an average resolution of 10 cM, for the identification of simple sequence tandem repeat polymorphisms (SSTRPs) that target new risk genes for Alzheimer disease (AD) by virtue of linkage disequilibrium. The efficiency of our association study was enhanced by genotyping pools of DNA from autopsy-confirmed cases with AD and matched controls. Allelic associations with AD were observed for 6 of the 391 SSTRPs in the CHLC Human Screening Set/Weber Version 6 (Research Genetics, Inc., Huntsville, AL): D1S518, D1S547, D10S1423, D12S1045, D19S178, and DXS1047. These allelic associations were replicated in an independent sample of autopsied AD cases and controls recruited from a geographically disparate site. The association of the large D19S178 alleles with AD appeared to arise from linkage disequilibrium with the APOE epsilon 4 allele, whose effect on increasing the risk of AD has been established. None of the remaining SSTRPs was in close proximity to loci previously reported to influence the risk of developing AD. Instead, they may identify five novel AD susceptibility loci. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/9653640/A_genome_survey_for_novel_Alzheimer_disease_risk_loci:_results_at_10_cM_resolution_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(98)95306-X DB - PRIME DP - Unbound Medicine ER -